Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.300 Biomarker phenotype CTD_human The BRAF V600E mutation is specifically associated with sporadic MSI+ CRCs with methylated MLH1, but is not associated with Lynch syndrome-related CRCs. 25701956 2015
Entrez Id: 6895
Gene Symbol: TARBP2
TARBP2 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 581
Gene Symbol: BAX
BAX 		0.300 Biomarker phenotype CTD_human Microsatellite instability: an update. 25701956 2015
Entrez Id: 57510
Gene Symbol: XPO5
XPO5 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 4437
Gene Symbol: MSH3
MSH3 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 92
Gene Symbol: ACVR2A
ACVR2A 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21 		0.300 Biomarker phenotype CTD_human As another new mechanism underlying MSI, overexpression of miR-155 or miR-21 has been shown to downregulate the expression of the MMR genes. 25701956 2015
Entrez Id: 29072
Gene Symbol: SETD2
SETD2 		0.300 Biomarker phenotype CTD_human Thus, mutations in the H3K36 trimethyltransferase SETD2 have been reported as a potential cause of MSI. 25701956 2015
Entrez Id: 406947
Gene Symbol: MIR155
MIR155 		0.300 Biomarker phenotype CTD_human As another new mechanism underlying MSI, overexpression of miR-155 or miR-21 has been shown to downregulate the expression of the MMR genes. 25701956 2015
Entrez Id: 100422821
Gene Symbol: MIR1273C
MIR1273C 		0.300 Biomarker phenotype CTD_human Microsatellite instability: an update. 25701956 2015
Entrez Id: 3066
Gene Symbol: HDAC2
HDAC2 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 8289
Gene Symbol: ARID1A
ARID1A 		0.300 Biomarker phenotype CTD_human Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype. 25701956 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.300 Biomarker phenotype CTD_human MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer. 17350979 2007
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2 		0.300 Biomarker phenotype CTD_human Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. 7761852 1995