Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5587
Gene Symbol: PRKD1
PRKD1
0.030 GeneticVariation disease BEFREE None of the PLGAs lacking PRKD1 somatic mutations or PRKD gene family rearrangements harboured somatic mutations in the kinase domains of the PRKD2 or PRKD3 genes. 26426580 2016
Entrez Id: 5587
Gene Symbol: PRKD1
PRKD1
0.030 GeneticVariation disease BEFREE We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. 25240283 2014
Entrez Id: 5587
Gene Symbol: PRKD1
PRKD1
0.030 GeneticVariation disease BEFREE The RNAseq of 2 CAMSGs showed ARID1A-PRKD1 and DDX3X-PRKD1 fusions, respectively, while no fusion candidates were identified in two PLGAs. 24942367 2014
Entrez Id: 6271
Gene Symbol: S100A1
S100A1
0.020 Biomarker disease BEFREE The morphology of 33 cases of PLGA was carefully evaluated using hematoxylin-and-eosin-stained sections and confirmed by immunohistochemistry for cytokeratin 7, vimentin, and S-100. 27591391 2017
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.020 Biomarker disease BEFREE The morphology of 33 cases of PLGA was carefully evaluated using hematoxylin-and-eosin-stained sections and confirmed by immunohistochemistry for cytokeratin 7, vimentin, and S-100. 27591391 2017
Entrez Id: 6271
Gene Symbol: S100A1
S100A1
0.020 AlteredExpression disease BEFREE Nine cases (60%) of polymorphous low-grade adenocarcinoma and two (13.3%) of adenoid cystic carcinoma met the criteria for significant co-expression of mammaglobin and S-100. 24029710 2013
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.020 AlteredExpression disease BEFREE Nine cases (60%) of polymorphous low-grade adenocarcinoma and two (13.3%) of adenoid cystic carcinoma met the criteria for significant co-expression of mammaglobin and S-100. 24029710 2013
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.010 AlteredExpression disease BEFREE Sixty-two cases of salivary gland neoplasms, including 25 mucoepidermoid carcinomas (MEC), 18 adenoid cystic carcinomas (ACC), 14 pleomorphic adenomas (PA) and 5 polymorphous low-grade adenocarcinoma (PLGA) were investigated for CXCR4 and CXCR7 expression immunohistochemically. 28772134 2017
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.010 AlteredExpression disease BEFREE The majority of MECs, ACCs and PLGAs showed high CXCR4 and CXCR7 expression, whereas most PAs showed high CXCR4 but low CXCR7 expression. 28772134 2017
Entrez Id: 55107
Gene Symbol: ANO1
ANO1
0.010 AlteredExpression disease BEFREE Mammaglobin and DOG-1 expression in polymorphous low-grade adenocarcinoma: an appraisal of its origin and morphology. 27591391 2017
Entrez Id: 3855
Gene Symbol: KRT7
KRT7
0.010 Biomarker disease BEFREE The morphology of 33 cases of PLGA was carefully evaluated using hematoxylin-and-eosin-stained sections and confirmed by immunohistochemistry for cytokeratin 7, vimentin, and S-100. 27591391 2017
Entrez Id: 947
Gene Symbol: CD34
CD34
0.010 Biomarker disease BEFREE We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. 28188441 2017
Entrez Id: 55304
Gene Symbol: SPTLC3
SPTLC3
0.010 Biomarker disease BEFREE We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. 28188441 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.010 Biomarker disease BEFREE Polymorphous low-grade adenocarcinoma has been confirmed to originate from the intercalated duct and to feature high expression of mammaglobin in its lobular pattern resembling that of mammary secretory analogue carcinoma, except for the ETV6 gene rearrangement. 27591391 2017
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.010 Biomarker disease BEFREE We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. 28188441 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.010 Biomarker disease BEFREE We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. 28188441 2017
Entrez Id: 23683
Gene Symbol: PRKD3
PRKD3
0.010 GeneticVariation disease BEFREE Given the kinase domain homology among PRKD1, PRKD2 and PRKD3, we sought to define whether PLGAs lacking PRKD1 somatic mutations or PRKD gene family rearrangements would be driven by somatic mutations affecting the kinase domains of PRKD2 or PRKD3. 26426580 2016
Entrez Id: 25865
Gene Symbol: PRKD2
PRKD2
0.010 Biomarker disease BEFREE A PRKD2 rearrangement was detected in one PLGA (6%). 24942367 2014
Entrez Id: 1654
Gene Symbol: DDX3X
DDX3X
0.010 GeneticVariation disease BEFREE The RNAseq of 2 CAMSGs showed ARID1A-PRKD1 and DDX3X-PRKD1 fusions, respectively, while no fusion candidates were identified in two PLGAs. 24942367 2014
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.010 Biomarker disease BEFREE These special histologic subtypes are characteristically negative for ER, PR, and HER2 (triple negative), and include adenoid cystic carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, and polymorphous low-grade adenocarcinoma. 22935826 2013
Entrez Id: 4781
Gene Symbol: NFIB
NFIB
0.010 Biomarker disease BEFREE Because of the well-known morphologic similarities between PLGA and adenoid cystic carcinoma (ACC) we also analyzed all tumors for expression of the recently identified ACC-associated MYB-NFIB gene fusion. aCGH analysis revealed that the PLGA genome contains comparatively few copy number alterations (CNAs). 21901247 2012
Entrez Id: 4602
Gene Symbol: MYB
MYB
0.010 AlteredExpression disease BEFREE RT-PCR analysis revealed that one of the 9 PLGAs expressed the ACC-associated MYB-NFIB gene fusion, illustrating the diagnostic difficulties associated with the diagnosis of these morphologically partly overlapping entities. 21901247 2012
Entrez Id: 9790
Gene Symbol: BMS1
BMS1
0.010 Biomarker disease BEFREE C-Kit expression (CD117) was common in ACC, generally mirroring that of CK7 and virtually lacking in PLGA. 21577319 2011
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.010 Biomarker disease BEFREE C-Kit expression (CD117) was common in ACC, generally mirroring that of CK7 and virtually lacking in PLGA. 21577319 2011
Entrez Id: 3815
Gene Symbol: KIT
KIT
0.010 AlteredExpression disease BEFREE C-Kit expression (CD117) was common in ACC, generally mirroring that of CK7 and virtually lacking in PLGA. 21577319 2011