Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Germline mutations in MLH1, MSH2 and MSH6 in Korean hereditary non-polyposis colorectal cancer families. 15365995 2004
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome. 8063241 1994
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. 9354786 1997
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. 24728189 2014
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations. 10521294 1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT A role for MLH3 in hereditary nonpolyposis colorectal cancer. 11586295 2001
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes. 28944238 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Risks of Lynch syndrome cancers for MSH6 mutation carriers. 20028993 2010
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Verification of the three-step model in assessing the pathogenicity of mismatch repair gene variants. 21120944 2011
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts. 27273229 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Population-based molecular screening for Lynch syndrome: implications for personalized medicine. 23733757 2013
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. 12658575 2003
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance. 15236168 2004
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry. 22949379 2013
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants. 22102614 2012
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Familial endometrial cancer in female carriers of MSH6 germline mutations. 10508506 1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer. 16807412 2006
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease UNIPROT Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. 10480359 1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study. 26552419 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer. 17453009 2007
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing. 25559809 2015
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients. 24763289 2014
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Feasibility of screening for Lynch syndrome among patients with colorectal cancer. 18809606 2008
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts. 18269114 2008