Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry. 22949379 2013
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome. 8063241 1994
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor. 16418736 2006
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population. 24728189 2014
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers. 12732731 2003
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC. 19851887 2010
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population. 18566915 2009
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome. 16283884 2005
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome. 21155762 2011
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes. 28944238 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Risks of Lynch syndrome cancers for MSH6 mutation carriers. 20028993 2010
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer. 17453009 2007
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer. 9929971 1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer. 21056691 2011
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts. 27273229 2017
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing. 26681312 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR MSH6 germline mutations are rare in colorectal cancer families. 14520694 2003
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients. 18301448 2008
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 GeneticVariation disease CLINVAR Population-based molecular screening for Lynch syndrome: implications for personalized medicine. 23733757 2013
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. 24362816 2014
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Germ-line msh6 mutations in colorectal cancer families. 10537275 1999
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer. 20487569 2010
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population. 27601186 2016
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden. 14961575 2004
Entrez Id: 2956
Gene Symbol: MSH6
MSH6 		0.700 CausalMutation disease CLINVAR Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. 22006311 2011