Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR A child with Li-Fraumeni syndrome: Modes to inactivate the second allele of TP53 in three different malignancies. 25787918 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A common gain of function of p53 cancer mutants in inducing genetic instability. 19881536 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion. 23792586 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene. 9047394 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A Li-Fraumeni syndrome family with retained heterozygosity for a germline TP53 mutation in two tumors. 12885464 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer. 11753428 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy? 11315715 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines. 20575032 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families. 10922393 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007. 18414213 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation. 20128691 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation. 20128691 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil. 21192060 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: 11 year follow-up of a prospective observational study. 27501770 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study. 21601526 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR BRCA1, TP53, and CHEK2 germline mutations in uterine serous carcinoma. 22811390 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR Cancer phenotype correlates with constitutional TP53 genotype in families with the Li-Fraumeni syndrome. 9764816 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Candidate gene analysis of BRCA1/2 mutation-negative high-risk Russian breast cancer patients. 25619955 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations. 22233476 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations. 22233476 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Choroid plexus carcinoma: a new case associated with a novel TP53 germ line mutation. 18208484 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 GeneticVariation disease CLINVAR Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management. 26484312 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning. 9667734 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Detection of 11 germline inactivating TP53 mutations and absence of TP63 and HCHK2 mutations in 17 French families with Li-Fraumeni or Li-Fraumeni-like syndrome. 11370630 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.100 CausalMutation disease CLINVAR Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India. 26911350 2016