×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Crystal structure of the WD40 domain dimer of LRRK2.
30635421
2019
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.
29212815
2018
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
30398148
2018
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.
29127255
2018
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
28720718
2017
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Structural interface between LRRK2 and 14-3-3 protein.
28202711
2017
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
Biomarker
disease
GENOMICS_ENGLAND
Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene.
28395804
2017
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
29125462
2017
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
Biomarker
disease
GENOMICS_ENGLAND
Reprogramming of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient with a R1628P variant in the LRRK2 gene.
28395802
2017
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
CLINVAR
The discovery of LRRK2 p.R1441S, a novel mutation for Parkinson's disease, adds to the complexity of a mutational hotspot.
27111571
2016
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
26824392
2016
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
26251043
2015
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
25201882
2014
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations.
24565865
2014
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.
23395371
2013
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
BEFREE
Mutations in the leucine-rich repeat kinase 2 (LRRK2 ) gene have been identified in pedigrees of autosomal-dominant familial Parkinson's disease (PARK8 ).
23924436
2013
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease.
22956510
2012
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.
23241745
2012
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis.
22575234
2012
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
UNIPROT
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death.
21850687
2011
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
21658387
2011
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.
21538529
2011
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
21494637
2011
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
GeneticVariation
disease
BEFREE
Mutations in PARK8 (LRRK2 ) are associated with autosomal dominant parkinsonism and Parkinson disease (PD).
18809839
2008
×
Entrez Id:
120892
Gene Symbol:
LRRK2
LRRK2
0.930
CausalMutation
disease
CLINVAR
The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study.
18986508
2008