Gene: PRKN ×
Source: UNIPROT ×
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. 22956510 2012
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant. 20889486 2011
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease. 21376232 2011
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. 20404107 2010
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. 20889974 2010
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. 19801972 2009
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. 19229105 2009
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Structure of the Parkin in-between-ring domain provides insights for E3-ligase dysfunction in autosomal recessive Parkinson's disease. 17360614 2007
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Novel parkin mutations detected in patients with early-onset Parkinson's disease. 15584030 2005
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. 12629236 2003
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. 12925569 2003
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Parkin mutations and susceptibility alleles in late-onset Parkinson's disease. 12730996 2003
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Role of parkin mutations in 111 community-based patients with early-onset parkinsonism. 12112109 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Linkage stratification and mutation analysis at the Parkin locus identifies mutation positive Parkinson's disease families. 12114481 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Relative high frequency of the c.255delA parkin gene mutation in Spanish patients with autosomal recessive parkinsonism. 12397156 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Complex relationship between Parkin mutations and Parkinson disease. 12116199 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Molecular findings in familial Parkinson disease in Spain. 12056932 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations. 11971093 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT [A new point mutation on exon 2 of parkin gene in Parkinson's disease]. 12362318 2002
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. 11431533 2001
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. 11590439 2001
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects. 11179010 2001
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT A novel Cys212Tyr founder mutation in parkin and allelic heterogeneity of juvenile Parkinsonism in a population from North West Colombia. 11163284 2001
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism. 11487568 2001
Entrez Id: 5071
Gene Symbol: PRKN
PRKN 		1.000 GeneticVariation disease UNIPROT Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism. 10939576 2000