Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.020 GeneticVariation disease BEFREE Patients with chronic low back and leg pain (CBLP) due to failed back surgery syndrome (FBSS) were screened for SCS according to the Dutch Neuromodulation Society guidelines. 30860645 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 AlteredExpression disease BEFREE Similarly, a significantly higher level of TNF-<i>α</i> and significantly lower level of IL-10 in FBSS patients than controls were observed. 30755780 2019
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.020 GeneticVariation disease BEFREE Prospective, Randomized, Sham-Control, Double Blind, Crossover Trial of Subthreshold Spinal Cord Stimulation at Various Kilohertz Frequencies in Subjects Suffering From Failed Back Surgery Syndrome (SCS Frequency Study). 29608229 2018
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.020 Biomarker disease BEFREE Allocation will be stratified by centre and minimised on patient age (≥ 65 or < 65 years), gender, presence of failed back surgery syndrome (or not) and use of high frequency (HF10™) (or not). 30446003 2018
Entrez Id: 7584
Gene Symbol: ZNF35
ZNF35
0.020 Biomarker disease BEFREE HF10-SCS offers a novel pain reduction tool without paresthesia for failed back surgery syndrome and chronic axial back pain. 29105244 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.020 Biomarker disease BEFREE Burst Spinal Cord Stimulation Increases Peripheral Antineuroinflammatory Interleukin 10 Levels in Failed Back Surgery Syndrome Patients With Predominant Back Pain. 28194840 2017
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
0.010 AlteredExpression disease BEFREE Levels of MMP-2 and TIMP-2 were higher in the FBSS group compared to the control group. 30620420 2019
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.010 Biomarker disease BEFREE The Elevated Serum Level of IFN-<i>γ</i> in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. 30755780 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.010 AlteredExpression disease BEFREE Levels of MMP-2 and TIMP-2 were higher in the FBSS group compared to the control group. 30620420 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.010 Biomarker disease BEFREE The impact of spinal cord stimulation (SCS) on serum levels of metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9) was assessed in a group of patients with failed back surgery syndrome (FBSS). 30620420 2019
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.010 Biomarker disease BEFREE The Elevated Serum Level of IFN-<i>γ</i> in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation. 30755780 2019