Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections.
Our findings represent novel roles for OMVs and the aminopeptidase in the modulation of <i>P. aeruginosa</i> biofilm architecture.<b>IMPORTANCE</b> Biofilm formation by the bacterial pathogen <i>P. aeruginosa</i> is known to contribute to drug resistance in nosocomial infections and chronic lung infections of cystic fibrosis patients.
We show that MPO genotype significantly influences the severity of pulmonary disease in early stages, prior to the development of chronic lung infections, with GG genotype being associated with more severe CF disease.