Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7272
Gene Symbol: TTK
TTK 		0.010 Biomarker disease BEFREE Valvular disease prevalence is similar to MPS I and II, but appears less severe. 29735373 2018
Entrez Id: 3425
Gene Symbol: IDUA
IDUA 		0.010 Biomarker disease BEFREE Valvular disease prevalence is similar to MPS I and II, but appears less severe. 29735373 2018
Entrez Id: 219972
Gene Symbol: MPEG1
MPEG1 		0.010 Biomarker disease BEFREE Valvular disease prevalence is similar to MPS I and II, but appears less severe. 29735373 2018
Entrez Id: 6232
Gene Symbol: RPS27
RPS27 		0.010 Biomarker disease BEFREE Valvular disease prevalence is similar to MPS I and II, but appears less severe. 29735373 2018
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.010 GeneticVariation disease BEFREE We found that patients with a FBN1 truncating or splicing mutation were more prone to developing severe aortic disease or valvular disease. 27611364 2016
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2 		0.010 AlteredExpression disease BEFREE The results show that matrix metalloproteinases MMP2 and MMP9, and matrix metalloproteinase inhibitors TIMP1 and TIMP2 mRNAs are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. 11400152 2001
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1 		0.010 AlteredExpression disease BEFREE The results show that matrix metalloproteinases MMP2 and MMP9, and matrix metalloproteinase inhibitors TIMP1 and TIMP2 mRNAs are synthesized in diseased valves and suggest that they may contribute to matrix remodelling in valvular disease. 11400152 2001
Entrez Id: 4318
Gene Symbol: MMP9
MMP9 		0.010 AlteredExpression disease BEFREE Signals for MMP9 mRNA were found in two cases with endocarditis and five cases with degenerative valvular disease. 11400152 2001
Entrez Id: 4313
Gene Symbol: MMP2
MMP2 		0.010 GeneticVariation disease BEFREE Synthesis of MMP2 mRNA was found in seven valves, five with endocarditis and two with degenerative valvular disease. 11400152 2001
Entrez Id: 4879
Gene Symbol: NPPB
NPPB 		0.010 AlteredExpression disease BEFREE Persistent AF was associated with higher mRNA expression of pro-BNP (+66%, P = 0.04, in patients without valvular disease, and +69%, P < 0.01, in patients with valvular disease) and lower mRNA expression of NPR-A (-58%, P = 0.02, in patients without valvular disease, and -62 %, P < 0.01, in patients with valvular disease). 10376920 1999