×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
GENOMICS_ENGLAND
Correction: Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease.
30171196
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
BEFREE
Knockdown of wfs1 , a fly homolog of Wolfram syndrome 1 , in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila.
29357349
2018
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
BEFREE
Wolfram syndrome 1 (WS ) is a rare neurodegenerative disease that is caused by mutations in the Wolfram syndrome 1 (WFS1 ) gene, which encodes the endoplasmic reticulum (ER) glycoprotein wolframin .
28901522
2017
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
BEFREE
Metabolomics of the Wolfram Syndrome 1 Gene (Wfs1 ) Deficient Mice.
29257731
2017
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
GENOMICS_ENGLAND
Dominant ER Stress-Inducing WFS1 Mutations Underlie a Genetic Syndrome of Neonatal/Infancy-Onset Diabetes, Congenital Sensorineural Deafness, and Congenital Cataracts.
28468959
2017
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Molecular diagnostic experience of whole-exome sequencing in adult patients.
26633545
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
GENOMICS_ENGLAND
A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY).
27185633
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
CLINVAR
Molecular diagnostic experience of whole-exome sequencing in adult patients.
26633545
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Lamination of the Outer Plexiform Layer in Optic Atrophy Caused by Dominant WFS1 Mutations.
26875006
2016
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in WFS1.
26435059
2015
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
CTD_human
Genetic studies in Drosophila and humans support a model for the concerted function of CISD2, PPT1 and CLN3 in disease.
24705017
2014
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
CLINVAR
Wolfram syndrome in the Japanese population; molecular analysis of WFS1 gene and characterization of clinical features.
25211237
2014
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
MGD
Energy metabolism and thyroid function of mice with deleted wolframin (Wfs1) gene.
24710642
2014
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Phenotypic characteristics of early Wolfram syndrome.
23981289
2013
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Wolfram syndrome: new mutations, different phenotype.
22238590
2012
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
UNIPROT
Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease.
22226368
2012
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
BEFREE
The causative gene for WS1 (WFS1 ) encoding wolframin maps to chromosome 4p16.1.
22790102
2012
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
MGD
Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene.
21031341
2011
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment.
21538838
2011
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
UNIPROT
Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment.
21538838
2011
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
GeneticVariation
disease
BEFREE
We have previously shown that mutations in the Wolfram syndrome 1 (WFS1 ) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress.
20160352
2010
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
CausalMutation
disease
CLINVAR
Congenital cataracts in two siblings with Wolfram syndrome.
21067485
2010
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
MGD
Wfs1 gene deletion causes growth retardation in mice and interferes with the growth hormone pathway.
19293327
2009
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
MGD
Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.
18343518
2008
×
Entrez Id:
7466
Gene Symbol:
WFS1
WFS1
0.980
Biomarker
disease
BEFREE
DNA analysis to examine single-nucleotide polymorphisms in 2 candidate modifier genes (ATP2B2 and Wolfram syndrome 1 [WFS1 ]) is summarized in this report.
18667942
2008