Disease: Hypercholesterolemia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885
LPA P08519 lipoprotein(a) Enzyme 6.6E-89 0.444 0.769
CD36 P16671 CD36 molecule Receptor 1.1E-60 0.446 0.846
ALMS1 Q8TCU4 ALMS1 centrosome and basal body associated protein 4.5E-60 0.559 0.808
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923
ABCC3 O15438 ATP binding cassette subfamily C member 3 Transporter 1.2E-26 0.517 0.769
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
CETP P11597 cholesteryl ester transfer protein 1.2E-23 0.512 0.731
ABCG5 Q9H222 ATP binding cassette subfamily G member 5 Transporter 3.1E-21 0.592 0.577
NPC1L1 Q9UHC9 NPC1 like intracellular cholesterol transporter 1 Transporter 2.3E-20 0.656 0.423
ABCG8 Q9H221 ATP binding cassette subfamily G member 8 Transporter 2.4E-20 0.573 0.538
PCSK9 Q8NBP7 proprotein convertase subtilisin/kexin type 9 Enzyme 2.7E-17 0.482 0.808
CYP4F2 P78329 cytochrome P450 family 4 subfamily F member 2 Enzyme 7.6E-17 0.674 0.308
APOB P04114 apolipoprotein B 1.9E-16 0.453 0.808
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846
ANGPTL3 Q9Y5C1 angiopoietin like 3 Signaling 1.6E-13 0.584 0.577
DHCR7 Q9UBM7 7-dehydrocholesterol reductase Enzyme 3.9E-13 0.500 0.846
FGFR4 P22455 fibroblast growth factor receptor 4 Kinase 7.2E-13 0.490 0.769
ABCB11 O95342 ATP binding cassette subfamily B member 11 Transporter 1.6E-12 0.566 0.654
VLDLR P98155 very low density lipoprotein receptor 2.0E-11 0.558 0.692
LIPG Q9Y5X9 lipase G, endothelial type Enzyme 1.0E-10 0.633 0.615
CYP2B6 P20813 cytochrome P450 family 2 subfamily B member 6 1.9E-10 0.428 0.846
NR1I2 O75469 nuclear receptor subfamily 1 group I member 2 Nuclear receptor 7.3E-09 0.418 0.846
ZPR1 O75312 ZPR1 zinc finger 8.9E-09 0.674 0.462
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654