|
rs3782025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One haplotype in the haplotype block at the 3' region of the gene that included rs3782025 was associated with AUD+ASPD in the Finns (P=.02) and with reduced alpha power in the Bethesda population (P=.00009).
|
19185213 |
2009 |
|
rs463379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, two-locus haplotypic analysis of rs6350-rs463379 did not further increase the strength of association with the quantitative Alcohol Use Disorder Identification Test score trait (P=0.0024).
|
19352220 |
2009 |
|
rs6350
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, two-locus haplotypic analysis of rs6350-rs463379 did not further increase the strength of association with the quantitative Alcohol Use Disorder Identification Test score trait (P=0.0024).
|
19352220 |
2009 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Adolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A118G (rs1799971), a single-nucleotide polymorphism (SNP) of the OPRM1 gene, and assessed for alcohol use disorder (AUD) diagnoses and other psychopathology.
|
19860800 |
2010 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydrofolate reductase (MTHFR, c.677C > T).
|
19637400 |
2010 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydrofolate reductase (MTHFR, c.677C > T).
|
19637400 |
2010 |
|
rs279871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives.
|
19783384 |
2010 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Chi-square analysis indicated that in female bipolar patients, there was a significant difference in genotype frequency between the bipolar patients with comorbid alcohol use disorder and non-comorbid bipolar patients for the Ser23Cys (rs6318) polymorphism of the 5HT2C gene.
|
20071033 |
2010 |
|
rs110402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs2836016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We then assessed rs2836016 in an adolescent sample of 261 subjects, which were characterized for early life stress and adolescent hazardous drinking, defined using the Alcohol Use Disorders Identification Test (AUDIT), to examine gene-environment interactions.
|
21307845 |
2011 |
|
rs3811939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages.
|
22781865 |
2012 |
|
rs1015443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a single nucleotide polymorphism (SNP) located within the TAS2R13 gene (rs1015443 [C1040T, Ser259Asn]), which showed a significant association with measures of alcohol consumption assessed via the Alcohol Use Disorders Identification Test (AUDIT).
|
22824251 |
2012 |
|
rs2306073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
|
rs4964057
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
|
rs7958822
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
|
22538398 |
2012 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This study provides initial evidence that the association between the A118G SNP of the OPRM1 gene and risk of AUDs is moderated by modifiable factors.
|
23136901 |
2013 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Lack of the ADH1B rs1229984 protective allele was significantly associated with consumption- and AUD-related phenotypes (OR = 1.77 for AUD; OR = 1.83 for risk drinking), while lack of the ADH1C rs698 protective allele was significantly associated with AUD-related phenotypes (OR = 2.32 for AUD).
|
23895337 |
2013 |
|
rs10044881
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis for two SNPs in HTR4 (rs17777298 and rs10044881) showed that the haplotype AG was significantly associated with the protective effect for AUD.
|
24312204 |
2013 |
|
rs17777298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis for two SNPs in HTR4 (rs17777298 and rs10044881) showed that the haplotype AG was significantly associated with the protective effect for AUD.
|
24312204 |
2013 |
|
rs56013859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At age 19 years, 268 young adults (126 males, 142 females) were genotyped for PER2 rs56013859 and were administered a 45-day alcohol timeline follow-back interview and the Alcohol Use Disorders Identification Test (AUDIT).
|
23533602 |
2013 |
|
rs698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lack of the ADH1B rs1229984 protective allele was significantly associated with consumption- and AUD-related phenotypes (OR = 1.77 for AUD; OR = 1.83 for risk drinking), while lack of the ADH1C rs698 protective allele was significantly associated with AUD-related phenotypes (OR = 2.32 for AUD).
|
23895337 |
2013 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results suggest that A118G (Asn40Asp) polymorphism may not have a major effect on the development of alcohol use disorders at least in the Finnish population.
|
23729673 |
2014 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A significant rs1229984 by childhood adversity interaction was observed for AUD symptoms in EA men.
|
25410943 |
2014 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs.
|
24988262 |
2014 |