|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Some studies show that AUD patients carrying the G-allele of the OPRM1 variant c.118A>G respond better to naltrexone, resulting in reduced relapse rates compared to carriers of the AA genotype.
|
30384381 |
2018 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A functional polymorphism of the mu-opioid receptor gene (OPRM1 A118G, rs1799971) may alter the risk of developing AUD.
|
29497164 |
2018 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
An association between AUD and a coding single nucleotide polymorphism (SNP) (rs1799971 encoding an Asn40Asp amino acid substitution, A118G) within the µ-opioid receptor 1 gene (OPRM1) has been reported.
|
25836994 |
2015 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
These results suggest that A118G (Asn40Asp) polymorphism may not have a major effect on the development of alcohol use disorders at least in the Finnish population.
|
23729673 |
2014 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
This study provides initial evidence that the association between the A118G SNP of the OPRM1 gene and risk of AUDs is moderated by modifiable factors.
|
23136901 |
2013 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Male children of alcoholics were less likely to be carriers of the G allele in single nucleotide polymorphism A118G (rs1799971), and those who were homozygous for the A allele were more likely to affiliate with alcohol use promoting peers who increased the risk for AUD symptoms at all ages.
|
22781865 |
2012 |
|
rs1799971
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Adolescents (n = 187; mean age = 15.4 years; 47.6% female) were genotyped for A118G (rs1799971), a single-nucleotide polymorphism (SNP) of the OPRM1 gene, and assessed for alcohol use disorder (AUD) diagnoses and other psychopathology.
|
19860800 |
2010 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
With longitudinal EHR data from the Million Veteran Program (MVP) linked to genetic data, we used two population-specific polymorphisms in ADH1B that are associated strongly with AUD in African Americans (AAs) and European Americans (EAs): rs2066702 (Arg369Cys, AAs) and rs1229984 (Arg48His, EAs) as criterion measures.
|
29972609 |
2018 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Therefore, among those at risk for greater consumption, e.g. those who experienced childhood adversity, ADH1B-rs1229984 appears to have a stronger effect on alcohol consumption and consequently on risk for AUD symptom severity.
|
24164917 |
2015 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A significant rs1229984 by childhood adversity interaction was observed for AUD symptoms in EA men.
|
25410943 |
2014 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs.
|
24988262 |
2014 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations.
|
25257461 |
2014 |
|
rs1229984
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Lack of the ADH1B rs1229984 protective allele was significantly associated with consumption- and AUD-related phenotypes (OR = 1.77 for AUD; OR = 1.83 for risk drinking), while lack of the ADH1C rs698 protective allele was significantly associated with AUD-related phenotypes (OR = 2.32 for AUD).
|
23895337 |
2013 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Multiple baseline pretreatment predictors of response were identified, including clinical (i.e., Body Mass Index (BMI), history of suicide, family history of alcohol use disorder), peripheral biochemistry (i.e., adiponectin levels, vitamin B12 levels), polysomnography (abnormalities in delta sleep ratio), neurochemistry (i.e., glutamine/glutamate ratio), neuroimaging (i.e., anterior cingulate cortex activity), genetic variation (i.e., Val66Met BDNF allele), and cognitive functioning (i.e., processing speed).
|
29673146 |
2018 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Multiple baseline pretreatment predictors of response were identified, including clinical (i.e., Body Mass Index (BMI), history of suicide, family history of alcohol use disorder), peripheral biochemistry (i.e., adiponectin levels, vitamin B12 levels), polysomnography (abnormalities in delta sleep ratio), neurochemistry (i.e., glutamine/glutamate ratio), neuroimaging (i.e., anterior cingulate cortex activity), genetic variation (i.e., Val66Met BDNF allele), and cognitive functioning (i.e., processing speed).
|
29673146 |
2018 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No significant associations, corrected for multiple comparisons, were found between the BDNF p.Val66Met polymorphism, brain volumes and AUD in adolescents with childhood trauma.
|
25510982 |
2014 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No significant associations, corrected for multiple comparisons, were found between the BDNF p.Val66Met polymorphism, brain volumes and AUD in adolescents with childhood trauma.
|
25510982 |
2014 |
|
rs6265
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydrofolate reductase (MTHFR, c.677C > T).
|
19637400 |
2010 |
|
rs759834365
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association of alcohol use disorder (AUD) with four candidate genes in older Korean men: aldehyde dehydrogenase 2 (ALDH2, 1/2), brain-derived neurotrophic factor (BDNF, val66met), serotonin transporter gene linked polymorphic region (5-HTTLPR, s/l), and methylenetetrahydrofolate reductase (MTHFR, c.677C > T).
|
19637400 |
2010 |
|
rs6971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also reveal for the first time an association in AUD participants between TSPO rs6971 genotype and plasma cholesterol, LDL, and triglyceride levels (not for HDL) and with withdrawal severity.
|
31713961 |
2019 |
|
rs6971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To show this common TSPO polymorphism impacts HPA rhythms in BD, we tested whether rs6971 (dichotomized: presence/absence of polymorphism) predicted variance in diurnal cortisol rhythm (saliva: morning and evening for 3 days) in 107 BD (50 with and 57 without AUD) and 28 healthy volunteers of similar age and ethno-demographic distribution.
|
29414032 |
2018 |
|
rs324981
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system.
|
26680586 |
2016 |
|
rs324981
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the general population, the NPSR1 Asn(107) Ile polymorphism is associated with AUD and alcohol consumption, dependent on sex, environment and age.
|
24754478 |
2015 |
|
rs6473797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, OPRK1 SNP rs6473797 was significantly related to the severity of alcohol-related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients.
|
31004399 |
2020 |
|
rs916264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genome-wide meta-analysis of EAA in AUD revealed a significant single nucleotide polymorphism (SNP), rs916264 (p = 5.43 × 10<sup>-8</sup>), in apolipoprotein L2 (APOL2) at the genome-wide level.
|
31466081 |
2020 |