Gene: ANG ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11701
rs11701
ANG ; RNASE4
0.040 GeneticVariation BEFREE The ANG rs11701 polymorphism was not associated with risk for ALS, FALS or SALS. 26753798

2016
dbSNP: rs11701
rs11701
ANG ; RNASE4
0.040 GeneticVariation BEFREE The molecular analysis of the ANG gene also demonstrated an allelic association with the rs11701 single nucleotide polymorphism (SNP) in familial ALS (FALS) but not in SALS patients. 17703939

2008
dbSNP: rs11701
rs11701
ANG ; RNASE4
0.040 GeneticVariation BEFREE We did not observe an association between patients with ALS and the rs11701 polymorphism, as previously reported in certain ALS populations of other ethnic origins. 18852347

2008
dbSNP: rs11701
rs11701
ANG ; RNASE4
0.040 GeneticVariation BEFREE Potentially causative missense variations in the ANG gene and a positive association with the synonymous rs11701-G substitution was detected mainly in Irish and Scottish ALS patients. 17462671

2007
dbSNP: rs121909536
rs121909536
ANG ; RNASE4
0.030 GeneticVariation BEFREE We generated SH-SY5Y neuroblastoma cell lines constitutively expressing wild type (WT) Hemagglutinin (HA) epitope tagged mouse Ang1 (mAng1), and two amyotrophic lateral sclerosis associated ANG variants (C39W and K40I). 31128105

2019
dbSNP: rs121909536
rs121909536
ANG ; RNASE4
0.030 GeneticVariation BEFREE Analysis of pooled odds ratios (ORs) and 95 % confidence intervals (CIs) revealed that the ANG K17I variant increases the risk for ALS (AT vs. AA: OR 2.65, 95 % CI 1.05-6.66, p = 0.038) and familial ALS (FALS) (AT vs. AA: OR 11.81, 95 % CI 2.11-66.15, p = 0.005) but not for sporadic ALS (SALS) (AT vs. AA: OR 1.63, 95 % CI 0.55-4.82, p = 0.378). 26255299

2015
dbSNP: rs121909536
rs121909536
ANG ; RNASE4
0.030 GeneticVariation BEFREE Accumulation of TDP-43 and alpha-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation. 19449021

2009
dbSNP: rs11541242
rs11541242
ANG ; RNASE4
0.020 GeneticVariation BEFREE Based on our studies, we provide a biological explanation for the loss-of-function of D22G-Angiogenin leading to ALS, and suggest that the L35P-Angiogenin mutation would probably cause ALS symptoms in individuals harboring this mutation. 25372031

2014
dbSNP: rs11541242
rs11541242
ANG ; RNASE4
0.020 GeneticVariation BEFREE Therefore, we predict that L35P mutant, would exhibit loss of angiogenic functions, and hence would correlate with ALS while K60E would not show any loss. 22384259

2012
dbSNP: rs121909539
rs121909539
ANG ; RNASE4
0.010 GeneticVariation BEFREE We generated SH-SY5Y neuroblastoma cell lines constitutively expressing wild type (WT) Hemagglutinin (HA) epitope tagged mouse Ang1 (mAng1), and two amyotrophic lateral sclerosis associated ANG variants (C39W and K40I). 31128105

2019
dbSNP: rs141055235
rs141055235
ANG ; RNASE4
0.010 GeneticVariation BEFREE Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation. 23228179

2013
dbSNP: rs17560
rs17560
ANG ; RNASE4
0.010 GeneticVariation BEFREE Therefore, we predict that L35P mutant, would exhibit loss of angiogenic functions, and hence would correlate with ALS while K60E would not show any loss. 22384259

2012
dbSNP: rs774017767
rs774017767
ANG ; RNASE4
0.010 GeneticVariation BEFREE Variants K17I, S28N, P112L and V113I have confirmed association with ALS, while T195C and A238G single nucleotide polymorphisms (SNPs) encoding L35P and K60E mutants respectively, have not been associated with ALS. 22384259

2012