|
rs750136455
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This proband inherited another missense mutation from her father (Glu-188-Gly). c) A missense mutation (G-7016-A; Asp-80-Asn) was observed in a single patient with AN who also harboured the 9bp insertion on a paternally derived haplotype. d) The allelic co-occurence of two silent mutations (C-6982-T and C-7285-T) was detected in two obese subjects. e) Two further silent mutations (C-3832-T; C-7111-G) were detected in an underweight and an obese subject, respectively.
|
9768693 |
1998 |
|
rs80326661
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This proband inherited another missense mutation from her father (Glu-188-Gly). c) A missense mutation (G-7016-A; Asp-80-Asn) was observed in a single patient with AN who also harboured the 9bp insertion on a paternally derived haplotype. d) The allelic co-occurence of two silent mutations (C-6982-T and C-7285-T) was detected in two obese subjects. e) Two further silent mutations (C-3832-T; C-7111-G) were detected in an underweight and an obese subject, respectively.
|
9768693 |
1998 |
|
rs1298806501
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both a) and b) were located within the flexible hinge region between DNA and ligand binding domain. c) For a 1082G-->A polymorphism we found suggestive evidence for an association between the more common 1082G-allele and anorexia nervosa (nominal p=0.04). d) One silent mutation (1421T-->C) was found solely in two obese probands. e) A common variant is located in the 3' nontranslated region at position 1730(A-->G).
|
9851804 |
1998 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase (COMT) is a candidate gene for mediating susceptibility to AN since it is involved in the dopamine catabolism and because its functional polymorphism (Val/Met 158) determines high (H) and low (L) enzymatic activity alleles.
|
11317231 |
2001 |
|
rs200960801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However an association was found at the ESR2 locus with the heterozygous genotype of the G1082A polymorphism and AN but not with any of the other ESR2 polymorphisms analysed.
|
11803451 |
2002 |
|
rs6318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between a non-conservative Cys23Ser in the 5-HT2c gene and anorexia nervosa in females was examined.
|
12858032 |
2003 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Because we were not able to support the primary hypothesis that Val158Met is a risk factor for AN, we did not perform secondary analysis of minimum body mass index (mBMI), age at onset or illness subtype (restricting or binge purging anorexia).
|
14681918 |
2004 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.
|
15115760 |
2004 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We previously reported a strong association of the Met66 allele of the Val66Met BDNF variant with restricting AN (ANR) and low minimum body mass index in Spanish patients.
|
15115760 |
2004 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.-46C > T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls.
|
15457498 |
2005 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.-46C > T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls.
|
15457498 |
2005 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Case-control studies also suggest a BDNF contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the BDNF gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and -270C/T BDNF SNPs and ED in six different European populations.
|
15657604 |
2005 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Case-control studies also suggest a BDNF contribution in the aetiology of ED: we have previously reported a strong association between the Met66 variant within the BDNF gene, restricting AN (ANR) and minimum body mass index (minBMI) in a Spanish sample, and a positive association between the Val66Met and -270C/T BDNF SNPs and ED in six different European populations.
|
15657604 |
2005 |
|
rs5030980
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.
|
15927146 |
2005 |
|
rs4680
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association was found between AN-R and several SNPs in the COMT-ARVCF region including the 158Val/Met polymorphism.
|
16118784 |
2005 |
|
rs495225
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the CC type of GHSR gene polymorphism (171T/C) is a risk factor for BN, but not for AN.
|
16362631 |
2006 |
|
rs554073050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the CC type of GHSR gene polymorphism (171T/C) is a risk factor for BN, but not for AN.
|
16362631 |
2006 |
|
rs6265
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BDNF has been involved in body weight regulation and its Val66Met polymorphism associated with AN.
|
17197106 |
2007 |
|
rs759834365
|
|
|
0.080 |
GeneticVariation |
BEFREE |
BDNF has been involved in body weight regulation and its Val66Met polymorphism associated with AN.
|
17197106 |
2007 |
|
rs5030980
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
rs1356639869
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
rs4684677
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
rs696217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
rs746682028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |
|
rs752298108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore re-investigated the association between AN and the Leu72Met and Gln90Leu polymorphisms of the prepro-ghrelin/obestatin gene, the Ala67Thr polymorphism of AgRP and the Val66Met polymorphism of BDNF taking into account clinical subtypes (restrictive--ANR--and bingeing/purging--ANB--subtypes).
|
17197106 |
2007 |