|
rs202085145
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1799971
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The data did not support a role for the Asn40Asp polymorphism in anxiety and depression, despite adequate statistical power to detect small effects.
|
12210283 |
2002 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
|
12796225 |
2003 |
|
rs63751273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
P301L mice had anxiety levels not different from wild-types, but their exploratory behavior was significantly increased.
|
15056457 |
2004 |
|
rs63750264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Tg-APP (Sw, V717F)/B6 mice at 11-14 months displayed decreased motor coordination, learning and memory deficits, and severely increased a</span>nxiety.
|
15114629 |
2004 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls matched to the patients for sex, age and ethnicity.
|
15450911 |
2004 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs1799971
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs75012854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs769540300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs774847933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehydrogenase 1B and aldehyde dehydrogenase 2 variants that cause the aversive flushing reaction; catechol-O-methyltransferase (COMT) Val158Met leading to differences in three aspects of neurobiology: executive cognitive function, stress/anxiety response, and opioid function; opioid receptor micro1 (OPRM1) Asn40Asp, which may serve as a gatekeeper molecule in the action of naltrexone, a drug used in alcoholism treatment; and HTTLPR, which alters serotonin transporter function and appears to affect stress response and anxiety/dysphoria, which are factors relevant to initial vulnerability, the process of addiction, and relapse.
|
15584875 |
2004 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.
|
15770238 |
2005 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects.
|
15770238 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health.
|
15900225 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
rs746682028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assuming that BDNF may be implicated in the putative common pathophysiology of depression and anxiety, we analyzed the association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C > T (formerly named C270T) in the noncoding region of exon V and 196G > A (val66met) in the coding region of exon XIIIA, with panic disorder.
|
15913870 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (ie low extraversion and high neuroticism) is unlikely to be wholly accounted for by the well-studied rs4680 ('val/met') polymorphism.
|
15956988 |
2005 |
|
rs63750424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the motor function and anxiety-related emotional response of R406W Tg mice were normal.
|
16182262 |
2005 |
|
rs8192506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks.
|
16904689 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate phenotypes including: dopaminergic system polymorphic variants (DRD2 -141C Ins/Del in promoter region, exon 8 and DRD2 TaqI A and DAT 40bp VNTR genes polymorphisms) that cause predisposition to severe alcoholism (haplotype Ins/G/A2); COMT Val158Met gene polymorphism related to differences in executive cognitive function and 5-HTT gene promoter polymorphism, which alters stress response and affects anxiety and dysphoria.
|
17079080 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a common functional polymorphism (val(158)met) that affects prefrontal function and working memory capacity and has also been associated with anxiety and emotional dysregulation.
|
17146014 |
2006 |
|
rs2478813
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was evidence of an allelic association between rs2478813 (and other single nucleotide polymorphisms correlated with it) and anxiety, depression, neuroticism, and psychological distress; the association with anxiety is significant after Bonferroni correction for multiple testing (empirical P<.001).
|
17339520 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adolescence: results from the Victorian Adolescent Health Cohort Study.
|
17504250 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness and magnitude; eg the functional Val(158)Met polymorphism in COMT is associated with obsessive-compulsive disorder in men, with anxiety phenotypes in women, and has a greater impact on cognitive function in boys than girls.
|
17805313 |
2008 |