|
rs1006737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UNPHASED analysis revealed that the rs1006737 A-allele was associated with lower extraversion and higher harm avoidance, trait anxiety, and paranoid ideation, while the rs10994336 T-allele was associated with lower novelty seeking and behavioral activation scores (p < 0.01).
|
21676128 |
2011 |
|
rs10112596
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From the phenotype analysis, anxiety was associated with GATA4 SNP rs10112596 among the AA group with AUD after a correction for multiple testing.
|
29415147 |
2018 |
|
rs1012176
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs1012176 showed the strongest association with any anxiety disorder (odds ratio: 0.8128, SE = 0.063, P = 0.00099), but this effect was not significant after correction for multiple testing.
|
24256404 |
2014 |
|
rs1043307
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found a positive association between PSMD9 rs1043307 and the presence of anxiety disorders in comorbidity with MDD, although this result was not significant following correction for multiple comparisons.
|
26624926 |
2015 |
|
rs104893877
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A53T (SNCA) and wild type (WT) littermate mice were evaluated for motor function (rotarod and stride length) and anxiety (elevated plus maze and open field) every 2 weeks.
|
23938351 |
2013 |
|
rs104893877
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, our results indicated that the novel environment-induced defecation response, a common method used to evaluate colorectal function, was not a useful test to measure exacerbation of GI dysfunction, most likely because of the reported reduced level of anxiety in A53T mice.
|
31709672 |
2020 |
|
rs104893877
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To test this, we used 3-, 5-, and 7-month-old A53T mice to examine anxiety-like behavior, locomotion, and expression of inflammation and astrogliosis markers in the Hipp and mCtx.
|
31417337 |
2019 |
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CNR1 rs1049353 G allele conferred an increased risk of antidepressant treatment resistance, particularly in female patients with high comorbid anxiety.
|
18579347 |
2008 |
|
rs1051730
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Mendelian randomisation analyses, there was no strong evidence that the minor allele of rs16969968/rs1051730 was associated with depression (OR=1.00, 95% CI 0.95 to 1.05), anxiety (OR=1.02, 95% CI 0.97 to 1.07) or psychological distress (OR=1.02, 95% CI 0.98 to 1.06) in current smokers.
|
25293386 |
2014 |
|
rs1051730
|
|
|
0.020 |
GeneticVariation |
BEFREE |
As there was no association of the smoking-related rs1051730 SNP with anxiety and depression among smokers, the results suggest that smoking is not a cause of anxiety and depression.
|
22687325 |
2013 |
|
rs10801153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We furthermore investigated the effect of rs10801153 on dimensional anxiety traits, a behavioral avoidance test (BAT), and an index for emotional processing in the respective subsets of the total sample.
|
25740197 |
2015 |
|
rs10835210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the human homologues of these genes were significantly associated with susceptibility for anxiety disorders (MMP9: rs3918242 and BDNF: rs6265, rs10835210 and rs11030107).
|
29288745 |
2018 |
|
rs10868235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Depressive disorders accounted for this results and independent variables associated with depressive disorders in TLE were female sex (OR=2.59; 95%CI=1.15-5.82; p=0.021), presence of concomitant anxiety disorders (OR=3.72; 95%CI=1.71-8.06; p=0.001) or psychotic disorders (OR=3.86; 95%CI=1.12-13.25; p=0.032), A/A genotype in the rs1867283 NTRK2 gene (OR=3.06; 95%CI=1.25-7.50; p=0.015) and C/C genotype in the rs10868235 NTRK2 gene (OR=3.54; 1.55-8.08; p=0.003).
|
28550723 |
2017 |
|
rs10893268
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.
|
25390645 |
2014 |
|
rs11030107
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three of these (BDNF: rs6265, rs10835210, rs11030107) were found to interact significantly with childhood trauma severity resulting in increased likelihood of an anxiety disorder diagnosis.
|
29288745 |
2018 |
|
rs110402
|
|
|
0.030 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Here, we provide clinical translation for the importance of these molecular interactions using an imaging genetics strategy to examine whether interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis.
|
26923505 |
2016 |
|
rs110402
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs11059336
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.
|
31123309 |
2019 |
|
rs1110976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At the 150 mg dose of caffeine, we found a significant association between caffeine-induced anxiety (Visual Analog Scales, VAS) and ADORA2A rs5751876 (1976C/T), rs2298383 (intron 1a) and rs4822492 (3'-flank), and DRD2 rs1110976 (intron 6).
|
18305461 |
2008 |
|
rs11111
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here we present an association study between eight (rs1981844, rs3812047, rs3096140, rs2973041, rs2910702, rs1549250, rs2973050 and rs11111) GDNF single nucleotide polymorphisms (SNPs) and anxiety and depression scores measured by the Hospital Anxiety and Depression Scale (HADS) on 708 Caucasian young adults with no psychiatric history.
|
24324616 |
2013 |
|
rs112146896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings were confirmed in a human sample where we observed a positive association of the EFhd2 single-nucleotide polymorphism rs112146896 with lifetime drinking and a negative association with anxiety in healthy adolescents.
|
28397836 |
2018 |
|
rs113209956
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.
|
31116379 |
2019 |
|
rs1132358
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By using a phenotype-based genetic association study, we identified two human BAIAP3 single-nucleotide polymorphism risk genotypes (AA for rs2235632, TT for rs1132358) that show a significant association with anxiety in women and, surprisingly, with benzodiazepine abuse in men.
|
23698091 |
2013 |
|
rs1133503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used a multi-stage association study approach starting with four psychiatric disorders to show an association between a MANEA single-nucleotide polymorphism (SNP; rs1133503) and anxiety disorders.
|
24473444 |
2014 |