|
rs120074192
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have investigated mechanisms by which the S1 domain S140G KCNQ1 mutation influences atrial arrhythmia risk and, additionally, whether it can affect ventricular electrophysiology.
|
24411289 |
2014 |
|
rs120074192
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, increased I(Ks) due to the KCNQ1 S140G mutation increases atrial susceptibility to arrhythmia due to increased tissue vulnerability, shortened ERP and altered atrial conduction velocity, which, in combination, facilitate initiation and maintenance of re-entrant excitation waves.
|
22508963 |
2012 |
|
rs120074192
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The purpose of this study was to further explore the association of the KCNQ1 S140G mutation with cardiac arrhythmias.
|
17467630 |
2007 |
|
rs1800172
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that use of NPSs, particularly synthetic cathinones, is associated with elevated risk of serious cardiac arrhythmia and sudden death for subjects carrying KCNQ1 G643S.
|
29855564 |
2018 |
|
rs1800172
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our present study suggests that administering psychotropic drug therapy to individuals carrying the G643S polymorphism may heighten the risk of prolonged QT intervals and life-threatening arrhythmias.
|
24284363 |
2014 |
|
rs120074195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study further substantiates a causal link between the V307L KCNQ1 mutation and pro-arrhythmia in human ventricles, and establishes partial inhibition of I<sub>Ks</sub> as a potential anti-arrhythmic strategy in SQT2.
|
28814790 |
2017 |
|
rs199472708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
(Heart Rhythm 11:67-75, 2014) to fit the behavior of I Ks due to the G229D mutation in KCNQ1 under a heterozygous mutant form.
|
26922794 |
2016 |
|
rs199473405
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arrhythmia formation in subclinical ("silent") long QT syndrome requires multiple insults: quantitative mechanistic study using the KCNQ1 mutation Q357R as example.
|
21952006 |
2012 |
|
rs1057128
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of KCNQ1 1638G>A, as well as the haplotype harboring KCNQ1 1638A, KCNQ1 1685 + 23G and 1732 + 43T (haplotype AGT) was significantly higher in healthy controls than in arrhythmia patients.
|
18426444 |
2008 |
|
rs1415058026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KCNJ2 mutations in arrhythmia patients referred for LQT testing: a mutation T305A with novel effect on rectification properties.
|
17341397 |
2007 |
|
rs199472762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A novel mutation (P343S) identified in the KCNQ1 subunit gene of three members of a RWS family showed a dominant-negative effect on native IKs currents leading to prolongation of the heart repolarisation and possibly increases the risk of malign arrhythmias with sudden cardiac death.
|
15511625 |
2004 |
|
rs199473401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Inderal or propanolol (a beta blocker) appears to be effective in preventing arrhythmias and syncope for an LQTS patient with the KCNQ1 L191P mutation.
|
12442276 |
2002 |