|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Besides, the risk of asthma progression was increased in patients with the VDR rs2228570 CC and VDBP rs7041 GG genotypes (OR = 3.56, P = .0382 and OR = 2.58, P = .01, respectively).
|
31541492 |
2020 |
|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Furthermore, we found that the rs2228570 genotype (OR, 3.763) of the VDR SNP and the vitamin D concentration (lower than 40 ng/ml, OR: 38.938) both contribute to increased susceptibility to bronchial asthma.
|
31719947 |
2019 |
|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis provides convincing evidence that rs2228570, rs7975232, rs731236 and rs3782905 gene polymorphisms in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphisms could be developed as biomarkers for asthma susceptibility.
|
27088875 |
2016 |
|
rs2228570
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Within the asthma cohort, multiple significant associations between SNPs and asthma characteristics were identified; VDR SNP rs2228570 was associated with the higher nighttime asthma morbidity scores (P = 0.04), lower baseline spirometric measures (P < 0.05), 1 or more positive aeroallergen skin test (P = 0.003), and increased immunoglobulin E levels (P < 0.001).
|
21613960 |
2011 |
|
rs7975232
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
rs7975232
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Rs10766197 of CYP2R1, rs7041 and rs4588 of CG, rs4646536 of CYP27B1, rs2228570, rs7975232, and rs1544410 of VDR, as well as rs1805192 and rs10865710 of PPAR were shown to be significantly associated with increased risk of bronchial asthma.
|
28590769 |
2017 |
|
rs7975232
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis provides convincing evidence that rs2228570, rs7975232, rs731236 and rs3782905 gene polymorphisms in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphisms could be developed as biomarkers for asthma susceptibility.
|
27088875 |
2016 |
|
rs7975232
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Although the susceptibility of VDR gene variants with asthma could not be confirmed for all SNPs tested in this study, the significant association obtained for rs7975232 provides evidence for a previously unknown report about the Chinese Han population and may raise the susceptibility of VDR to be a candidate gene for asthma.
|
19622139 |
2009 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
rs1544410
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In subgroup analyses by type of disease, we confirmed positive results for rs1544410 BsmI polymorphism in both asthma and atopic dermatitis, and for rs731236 TaqI polymorphism in atopic dermatitis.
|
31752548 |
2020 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis was performed to identify whether VDR gene polymorphisms (FokI (rs2228570) or TaqI (rs731236) or BsmI (rs1544410) or ApaI (rs7975232)) play a role in the risk of asthma.
|
31654764 |
2020 |
|
rs731236
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis provides convincing evidence that rs2228570, rs7975232, rs731236 and rs3782905 gene polymorphisms in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphisms could be developed as biomarkers for asthma susceptibility.
|
27088875 |
2016 |
|
rs3782905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis provides convincing evidence that rs2228570, rs7975232, rs731236 and rs3782905 gene polymorphisms in VDR are associated with increased susceptibility to asthma, indicating VDR polymorphisms could be developed as biomarkers for asthma susceptibility.
|
27088875 |
2016 |
|
rs2239185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma.
|
19745160 |
2010 |