Gene: IL33 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs146597587
rs146597587
IL33 ; LOC107987046
0.720 GeneticVariation BEFREE This includes a rare splice acceptor variant (rs146597587, MAF = 0.5%) in interleukin 33 (IL33) associated with reduced eosinophil count (P = 2.4x10-23), and lower risk of asthma (P = 2.6x10-7, odds ratio [95% confidence interval] = 0.56 [0.45-0.70]) and allergic rhinitis (P = 4.2x10-4, odds ratio = 0.55 [0.39-0.76]). 28787443

2017
dbSNP: rs146597587
rs146597587
IL33 ; LOC107987046
0.720 GeneticVariation BEFREE Together these data demonstrate that rs146597587-C is a loss of function mutation and support the hypothesis that IL-33 haploinsufficiency protects against asthma. 28273074

2017
dbSNP: rs7044343
rs7044343
IL33 ; LOC107987046
0.010 GeneticVariation BEFREE No association was found between rs7044343 variant and asthma. 28985997

2018
dbSNP: rs12551256
rs12551256
IL33 ; LOC107987046
0.010 GeneticVariation BEFREE The G allele of IL33 SNP rs12551256 was negatively associated with asthma (OR 0.71, 95% CI: 0.53-0.94, P = 0.017). 28266165

2017