|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D.
|
25498133 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial.
|
23957567 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent.
|
27018938 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The val66met single-nucleotide polymorphism (SNP) showed significant (P = 0.005) association for valine (allele G) with schizophrenia but not bipolar disorder.
|
15630410 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Changes in gyrification over 4 years in bipolar disorder and their association with the brain-derived neurotrophic factor valine(66) methionine variant.
|
19167700 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder.
|
17417060 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study suggests that the markers examined thus far in COMT and SLC6A4 are not associated with pediatric bipolar disorder and that if the val66met marker in BDNF is associated with pediatric bipolar disorder the magnitude of the association is much smaller than first reported.
|
19193231 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val66Met polymorphism of the BDNF gene may be associated with cognitive performance on the WCST in bipolar mood disorder but not in schizophrenia.
|
16472361 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests.
|
22484201 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the association between the BDNF Val66Met and DRD3 Ser9Gly polymorphisms with two subtypes of bipolar disorder: bipolar-I and -II.
|
22877924 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder.
|
26528762 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
|
15336520 |
2004 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
|
16388065 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD.
|
24862657 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF rs6265 was associated with St in the BD group (p = 0.017).
|
30041166 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study also adds to the body of evidence associating the functional Val66Met polymorphism of BDNF with BD.
|
22085476 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.
|
25539739 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder.
|
16538178 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the neurochemistry of the left dorsolateral prefrontal cortex of bipolar disorder and healthy participants in relation to the brain-derived neurotrophic factor val66met polymorphism using H-magnetic resonance spectroscopy.
|
17885603 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD.
|
27905499 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration.
|
24398043 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further studies are needed to evaluate the genetic association between the val66met allele and the BD-PTSD population, along with central/peripheral BDNF levels and epigenetic patterns of BDNF gene regulation within these patients.
|
21931317 |
2012 |