Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Few genetic studies exploring the impact of Val66Met on cognition in BD. 30078664

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Few genetic studies exploring the impact of Val66Met on cognition in BD. 30078664

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF rs6265 was associated with St in the BD group (p = 0.017). 30041166

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. 28479278

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. 28479278

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. 27018938

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD. 27905499

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD. 27209073

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies. 27236043

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. 27018938

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We concluded that changes in plasma BDNF levels significantly correlated with changes in WCST scores in BD and is moderated by the BDNF Val66Met polymorphism and the subtype of BD. 27905499

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Although the Val66Met polymorphism at the BDNF gene does not seem to play a significant role in children and adolescents with BD or ADHD, BDNF serum levels deserve further attention in future research on neurobiological aspects of BD and ADHD. 27209073

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies. 27236043

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE DNA samples from the Treatment of Early Age Mania (TEAM) and Mayo Clinic Bipolar Disorder Biobank were investigated for association of rs6265 with early-onset bipolar disorder. 26528762

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>. 25041243

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Although the present study has some limitations, the results indicate a lack of association between the Val66Met polymorphism and bipolar disorder</span>. 25041243

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder. 26528762

2015

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE We aimed to explore whether anxiety in BD offspring was associated with the BDNF Val66Met polymorphism.64 BD offspring (mean age: 13.73 (S.D. 25498133

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Val66Met polymorphism and serum brain-derived neurotrophic factor in bipolar disorder: an open-label trial. 23957567

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF val66met polymorphism is a potential vulnerability factor for cognitive impairment in BD. 24862657

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis. 25539739

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Plasma BDNF concentration did not differ by val66met or BD subtype, nor was it correlated with age or illness duration. 24398043

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Here we investigated a two hit gene environment model in relation to functional genomic factors (BDNF mRNA), and volume of hippocampal subfields in schizophrenia spectrum and bipolar disorders, focusing on both an environmental (childhood trauma) and genetic risk factor (BDNF val66met). 25246365

2014

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. 24468644

2014