|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated sex-specific genetic associations between variants of P2RX7 (rs1621388 and rs2230912) in 756 patients with bipolar disorder and 787 control patients matched on age, sex, and ancestry.
|
30445384 |
2019 |
|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We found a significant association between rs2230912 and combined mood disorders (major depressive disorder (MDD) or bipolar disorder (BD)) for the allelic, dominant and heterozygous-disadvantage model, all withstanding the threshold of correction for multiple testing.
|
29122639 |
2018 |
|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Comprehensive investigation of the P2X7R Gln460Arg missense mutation (rs2230912), which has been associated with major depression and bipolar disorder, has substantially contributed to validate P2X7R as a potential genetic risk factor.
|
30093269 |
2018 |
|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
These results indicate that heterozygosity for the wild-type P2X7R and its mood disorder-associated variant P2X7R-Gln460Arg represents a genetic risk factor, which is potentially able to convey susceptibility to mood disorders.<b>SIGNIFICANCE STATEMENT</b> Depression and bipolar disorder are the most common mood disorders.
|
29079688 |
2017 |
|
rs2230912
|
|
|
0.060 |
GeneticVariation |
BEFREE |
A non-synonymous coding SNP in the P2RX7 gene (rs2230912), previously found to be associated with bipolar disorder, was significantly associated (P=0.0019) with MDD.
|
16822851 |
2006 |
|
rs1621388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated sex-specific genetic associations between variants of P2RX7 (rs1621388 and rs2230912) in 756 patients with bipolar disorder and 787 control patients matched on age, sex, and ancestry.
|
30445384 |
2019 |
|
rs1718119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs2230911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |
|
rs3751143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we aimed to investigate the C-terminal region of this gene in major depressive and bipolar disorders (MDD and BD) by studying possibly functional, non-synonymous polymorphisms within a 7 kb long region around the Gln460Arg, including Ala348Thr (rs1718119), Thr357Ser (rs2230911), and Glu496Ala (rs3751143) variants.
|
30664971 |
2019 |