In the current study, we investigated the associations of single nucleotide polymorphisms (SNPs) in miRNAs (rs11134527 in <i>pri-miR-218-2</i>, rs74693964 in <i>pri-miR-145</i>, rs6062251 in <i>pri-miR-133a-2</i>, and rs4705343 in <i>pri-miR-143</i>) with nonsmall cell lung cancer (NSCLC) in a Han population from Yunnan Province, Southwest China using a binary logistic regression analysis.