The aim of this study is to evaluate the levels of soluble CTLA-4 (sCTLA-4) in human papillomavirus (HPV)-infected women with or without CaCx and their association with the polymorphism at CTLA-4 + 49 A/G and CTLA-4 -318 C/T genotypes.
Our results suggested that both T allele frequency (OR = 1.63, 95 % CI 1.06-2.50; P = 0.03) and (TT + CT) genotype distribution (OR = 1.72, 95 % CI 1.07-2.77; P = 0.03) of the rs5742909 were associated with risk for cervical cancer.