|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also compared the distribution and frequency of APC mutations from colon tumors that were positive and negative for the I1307K mutation.
|
9869603 |
1999 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also compared the distribution and frequency of APC mutations from colon tumors that were positive and negative for the I1307K mutation.
|
9869603 |
1999 |
|
rs2273535
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified a common genetic variant in STK15 (resulting in the amino acid substitution F31I) that is preferentially amplified and associated with the degree of aneuploidy in human colon tumors.
|
12881723 |
2003 |
|
rs113488022
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Here, we examined the effect of colon tumor-associated B-Raf mutations within the kinase activation segment, including V599E, on extracellular signal-regulated kinase (Erk) and nuclear factor kappaB (NFkappaB) signaling, and on the transformation of NIH3T3 fibroblasts.
|
14678966 |
2003 |
|
rs121913377
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Here, we examined the effect of colon tumor-associated B-Raf mutations within the kinase activation segment, including V599E, on extracellular signal-regulated kinase (Erk) and nuclear factor kappaB (NFkappaB) signaling, and on the transformation of NIH3T3 fibroblasts.
|
14678966 |
2003 |
|
rs1463038513
|
|
|
0.020 |
GeneticVariation |
BEFREE |
From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
|
15733272 |
2005 |
|
rs1801155
|
|
|
0.020 |
GeneticVariation |
BEFREE |
From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
|
15733272 |
2005 |
|
rs113488022
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Recently, it was shown that the oncogenic activation of BRAF, a member of the RAS/RAF family of kinases, by the V600E mutation is characteristic for sporadic colon tumors with microsatellite instability.
|
15782118 |
2005 |
|
rs121913377
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Recently, it was shown that the oncogenic activation of BRAF, a member of the RAS/RAF family of kinases, by the V600E mutation is characteristic for sporadic colon tumors with microsatellite instability.
|
15782118 |
2005 |
|
rs2273535
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A genetic variant in STK15 T+91A (resulting in the amino acid substitution F31I) is associated with increased aneuploidy in colon tumors and cell transformation in vitro.
|
15802297 |
2005 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their associations with colon tumor characteristics, including acquired mutations in Ki-ras and p53 genes and microsatellite instability (MSI).
|
16177213 |
2005 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their associations with colon tumor characteristics, including acquired mutations in Ki-ras and p53 genes and microsatellite instability (MSI).
|
16177213 |
2005 |
|
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated 2 polymorphisms in the MTHFR gene (C677T and A1298C) and their associations with colon tumor characteristics, including acquired mutations in Ki-ras and p53 genes and microsatellite instability (MSI).
|
16177213 |
2005 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study suggests that MDR1 2677G>T and 3435C>T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors.
|
17674045 |
2008 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study suggests that MDR1 2677G>T and 3435C>T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors.
|
17674045 |
2008 |
|
rs12953717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At 18q21, associations were observed in distal colon tumors but not in proximal or rectal cancers: rs4939827 (P(trend) = 0.007; per allele OR, 0.77; 95% CI, 0.64-0.93; case-case p(diff) = 0.03) and rs12953717 (P(trend) = 0.01; per allele OR, 1.27; 95% CI, 1.06-1.52).
|
19155440 |
2009 |
|
rs4939827
|
|
|
0.010 |
GeneticVariation |
BEFREE |
At 18q21, associations were observed in distal colon tumors but not in proximal or rectal cancers: rs4939827 (P(trend) = 0.007; per allele OR, 0.77; 95% CI, 0.64-0.93; case-case p(diff) = 0.03) and rs12953717 (P(trend) = 0.01; per allele OR, 1.27; 95% CI, 1.06-1.52).
|
19155440 |
2009 |
|
rs412396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FRAP1 was associated with microsatellite instability (MSI)+ colon tumors; PRKAA1, CpG island methylator phenotype (CIMP)+ and MSI+ colon tumors; PRKAG2 and KRAS2 colon tumors; TSC1 and CIMP+ and MSI+ colon tumors; TSC2 with MSI+ colon tumors; PIK3CA with KRAS2-mutated rectal tumors; PRKAG2 (rs6964824) with KRAS2- and TP53-mutated rectal tumors and with PRKAG2 (rs412396 and rs4725431) with CIMP+ rectal tumors.
|
20622004 |
2010 |
|
rs4725431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FRAP1 was associated with microsatellite instability (MSI)+ colon tumors; PRKAA1, CpG island methylator phenotype (CIMP)+ and MSI+ colon tumors; PRKAG2 and KRAS2 colon tumors; TSC1 and CIMP+ and MSI+ colon tumors; TSC2 with MSI+ colon tumors; PIK3CA with KRAS2-mutated rectal tumors; PRKAG2 (rs6964824) with KRAS2- and TP53-mutated rectal tumors and with PRKAG2 (rs412396 and rs4725431) with CIMP+ rectal tumors.
|
20622004 |
2010 |
|
rs6964824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FRAP1 was associated with microsatellite instability (MSI)+ colon tumors; PRKAA1, CpG island methylator phenotype (CIMP)+ and MSI+ colon tumors; PRKAG2 and KRAS2 colon tumors; TSC1 and CIMP+ and MSI+ colon tumors; TSC2 with MSI+ colon tumors; PIK3CA with KRAS2-mutated rectal tumors; PRKAG2 (rs6964824) with KRAS2- and TP53-mutated rectal tumors and with PRKAG2 (rs412396 and rs4725431) with CIMP+ rectal tumors.
|
20622004 |
2010 |
|
rs1961177
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CT/TT genotypes of rs1961177 were significantly associated with an increased likelihood of a MSI+ colon tumor (OR 1.77 95% CI 1.26-2.37).
|
21479914 |
2011 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Higher frequency of Met allele of XRCC3 Thr241Met was detected in patients treated with neoadjuvant chemoradiotherapy (p = 0.024, OR: 5.25; 95% CI: 1.23-23.39) and with proximal colon tumors (p = 0.04, OR: 2; 95% CI: 1.18-3.34).
|
21561390 |
2011 |
|
rs113488022
|
|
T |
0.770 |
GeneticVariation |
CLINVAR |
To investigate the cause of the limited therapeutic effect of PLX4032 in BRAF(V600E) mutant colon tumours, here we performed an RNA-interference-based genetic screen in human cells to search for kinases whose knockdown synergizes with BRAF(V600E) inhibition.
|
22281684 |
2012 |
|
rs113488022
|
|
|
0.770 |
GeneticVariation |
BEFREE |
To investigate the cause of the limited therapeutic effect of PLX4032 in BRAF(V600E) mutant colon tumours, here we performed an RNA-interference-based genetic screen in human cells to search for kinases whose knockdown synergizes with BRAF(V600E) inhibition.
|
22281684 |
2012 |
|
rs121913377
|
|
|
0.770 |
GeneticVariation |
BEFREE |
To investigate the cause of the limited therapeutic effect of PLX4032 in BRAF(V600E) mutant colon tumours, here we performed an RNA-interference-based genetic screen in human cells to search for kinases whose knockdown synergizes with BRAF(V600E) inhibition.
|
22281684 |
2012 |