Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.900 | GeneticVariation | BEFREE | Among those without distant disease at diagnosis, CRC-specific survival differed by genotype only for NSAID users: each minor allele of rs4939827 was associated with worse survival [hazard ratio (HR) = 2.67, 95% confidence interval (CI): 1.33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94). | 21910156 | 2011 |
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0.900 | GeneticVariation | BEFREE | Two recent genome-wide association studies (GWAS) identified three common variants in SMAD7 (rs4464148, rs4939827 and rs12953717) that confer modest susceptibility to colorectal cancer. | 19357349 | 2009 |
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T | 0.900 | GeneticVariation | GWASDB | Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. | 18372901 | 2008 |
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0.900 | GeneticVariation | GWASDB | Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. | 19011631 | 2008 |
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T | 0.900 | GeneticVariation | GWASCAT | Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. | 18372901 | 2008 |
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T | 0.900 | GeneticVariation | GWASCAT | Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)). | 17934461 | 2007 |
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T | 0.900 | GeneticVariation | GWASDB | Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)). | 17934461 | 2007 |
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0.900 | GeneticVariation | BEFREE | Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)). | 17934461 | 2007 |