Gene: IGF1 ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6214
rs6214
IGF1 ; HELLPAR ; LINC02456
0.030 GeneticVariation BEFREE In this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction. 24608110

2014
dbSNP: rs6214
rs6214
IGF1 ; HELLPAR ; LINC02456
0.030 GeneticVariation BEFREE The associations of four single nucleotide polymorphisms (SNPs) in IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), and IRS2 (rs2289046) genes with the risk of CRC were evaluated using a case-control design with 167 CRC cases and 277 controls by the PCR-RFLP method. 24175768

2013
dbSNP: rs6214
rs6214
IGF1 ; HELLPAR ; LINC02456
0.030 GeneticVariation BEFREE Our results suggest that the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements. 19784788

2010
dbSNP: rs35767
rs35767
IGF1 ; LOC105369944
0.020 GeneticVariation BEFREE However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective. 30334445

2018
dbSNP: rs35767
rs35767
IGF1 ; LOC105369944
0.020 GeneticVariation BEFREE The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer. 19784788

2010