|
rs1800872
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A decreased risk of colorectal cancer in subjects with rs1800872 AC genotype of IL10 (OR = 0.643, 95%CI = 0.453, 0.912) or AC/CC genotype (OR = 0.636, 95%CI = 0.457, 0.885) was observed, compared with those with AA genotype.
|
24762198 |
2014 |
|
rs1800872
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We found indications that aspirin interacted with rs6983267 close to MYC (encoding a transcription factor involved in cell cycle progression, apoptosis and cellular transformation) and NSAIDs interacted with rs3024505 and rs1800872 in or close to IL10 (encoding IL-10) in preventing CRC.
|
24889212 |
2014 |
|
rs1800896
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The role of functional polymorphism within IL10 (rs1800896) in colorectal cancer (CRC) still remains elusive.
|
25209180 |
2014 |
|
rs1800896
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A case-control study of 401 cases and 300 sex- and age-matched controls was performed in order to explore the role of IL1B_1473G/C (rs1143623), SOD1_7958A/G (rs4998557), TLR4_1196C/T (rs4986791), IL10_1082A/G (rs1800896), IL17A_197G/A (rs2275913), and TLR4_896A/G (rs4986790) polymorphisms in the susceptibility to colorectal cancer (n = 244), gastric carcinoma (n = 72), and ovarian cancer (n = 85).
|
24446182 |
2014 |
|
rs1800872
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The polymorphisms IL10 C-592A (rs1800872), C-rs3024505-T, IL1b C-3737T (rs4848306), G-1464C (rs1143623), T-31C (rs1143627) and PTGS2 (encoding COX-2) A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) were assessed in relation to risk of colorectal cancer (CRC) and interaction with diet (red meat, fish, fibre, cereals, fruit and vegetables) and lifestyle (non-steroid-anti-inflammatory drug use and smoking status) was assessed in a nested case-cohort study of nine hundred and seventy CRC cases and 1789 randomly selected participants from a prospective study of 57,053 persons.
|
24194923 |
2013 |
|
rs1800872
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Based on this meta-analysis, we conclude that the IL-10 rs1800872 polymorphism could be a risk factor for CRC development among European populations.
|
23079832 |
2012 |
|
rs1800896
|
|
|
0.040 |
GeneticVariation |
BEFREE |
However, we found no association between the IL-10 rs1800896 polymorphism and CRC risk.
|
23079832 |
2012 |
|
rs1800896
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Compared with the AA genotype at the candidate IL10-1082 locus (rs1800896), carrying one (OR, 0.79; 95% CI, 0.53-1.18) or two (OR, 0.58; 95% CI, 0.35-0.95) G alleles, a known higher producer of the anti-inflammatory cytokine IL-10, was associated with lower risk of colorectal cancer (p trend = 0.03).
|
19760027 |
2009 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1143634 in the interleukin-1β (IL1B) gene and rs1800871 in the interleukin-10 (IL10) gene were associated with increased risk for CRC in the Han Chinese.
|
24557062 |
2015 |