Then, we performed a two-stage case-control study consisting of 2347 cases and 3390 controls, and found a positive polymorphism rs1062044</span>, which presented consistently significant associations with CRC in both stages, and with an odds ratio (OR) = 1.32 (95% confidence interval (95%CI) = 1.18-1.49, P = 3.43E-06) under the dominant model in the combined study.
These findings strongly suggest that the functional SNP located at TFBSs, r</span>s6695837 might contribute to CRC susceptibility, and the exact biological mechanism awaits further research.