|
rs11591147
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The rs11591147 T allele was associated with 0.5 mmol/L lower LDL-C level (P = 9 × 10-143) and 23% lower CHD risk [odds ratio (OR): 0.77, 95% confidence interval (CI): 0.69-0.87, P = 7 × 10-6].
|
29020353 |
2018 |
|
rs11591147
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphism (SNP) rs11591147 has been associated with lower LDL-cholesterol and a lower risk of coronary heart disease.
|
23300213 |
2013 |
|
rs11591147
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
rs11591147
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The R46L variant in the proprotein-convertase subtilisin-kexin type 9 (PCSK9) gene was associated with reduced levels of LDL and total cholesterol and with a lower risk of coronary artery disease.
|
20699424 |
2010 |
|
rs11591147
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk.
|
18262190 |
2008 |
|
rs11591147
|
|
|
0.750 |
GeneticVariation |
BEFREE |
In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9) gene and its association with plasma lipid levels and CHD (coronary heart disease) in healthy U.K. men and patients with clinically defined definite FH (familial hypercholesterolaemia).
|
17550346 |
2007 |
|
rs505151
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The associations between proprotein convertase subtilisin/kexin type 9 E670G polymorphism and the risk of coronary artery disease and serum lipid levels: a meta-analysis.
|
26576960 |
2015 |
|
rs505151
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Effect of E670G Polymorphism in PCSK9 Gene on the Risk and Severity of Coronary Heart Disease and Ischemic Stroke in a Tunisian Cohort.
|
24599757 |
2014 |
|
rs505151
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan.
|
19191720 |
2009 |
|
rs505151
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9) gene and its association with plasma lipid levels and CHD (coronary heart disease) in healthy U.K. men and patients with clinically defined definite FH (familial hypercholesterolaemia).
|
17550346 |
2007 |
|
rs752506225
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ANXA2-R1 domain coding-SNP rs17845226 (V98L) associated with LDL-C, homozygotes for the minor allele having ≈18.8% higher levels of LDL-C (p = 0.004), and higher risk of coronary heart disease (CHD) (p = 0.04).
|
28456096 |
2017 |
|
rs28362286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The overall high frequency of the cardioprotective C679X mutation in Africa may contribute to the lower incidence of CHD on this continent.
|
18652535 |
2008 |
|
rs67608943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two nonsense mutations, Y142X and C679X, are associated to lifelong hypocholesterolemia and a remarkable protection against coronary heart disease (CHD) in African Americans.
|
18652535 |
2008 |
|
rs562556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9) gene and its association with plasma lipid levels and CHD (coronary heart disease) in healthy U.K. men and patients with clinically defined definite FH (familial hypercholesterolaemia).
|
17550346 |
2007 |