|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ABCB1 3435C>T and 2677G>T/A polymorphisms in Polish and Bosnian patients with Crohn's disease - A preliminary report.
|
28759738 |
2017 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have detected no significant association of C3435T SNP and pediatric CD.
|
27603561 |
2016 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively).
|
25346426 |
2015 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Heterozygous carriers for C3435T were significantly less likely to have CD (p=0.02; OR 0.58, 95% CI (0.36-0.91)).
|
23537364 |
2013 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C3435T polymorphism of the ABCB1/MDR1 gene is not a risk factor for IBD, including UC and CD, in the population coming from central Poland.
|
22661185 |
2012 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Allele frequencies of the cyclooxygenase 2 (COX-2/PTGS2/PGHS2) G-765C and breast cancer resistance protein (BCRP/ABCG2) C421A as well as allele and haplotype frequencies of multidrug resistance 1 (MDR1, ABCB1) SNPs G2677T/A, C3435T and G-rs3789243-A (intron 3) were assessed in a Danish case-control study comprising 373 CD and 541 UC patients and 796 healthy controls.
|
18819034 |
2009 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD.
|
19107781 |
2009 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three hundred eighty-eight German IBD patients [244 with Crohn's disease (CD), 144 with ulcerative colitis (UC)] and 1,005 German healthy controls were genotyped for the two MDR1 SNPs on positions 2677G>T/A and 3435C>T.
|
17665184 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).
|
17262810 |
2007 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association of MDR1 C3435T with CD was observed (CC vs (CT + TT): P = 0.007; OR [95% CI] = 1.58 [1.12-2.23]).
|
16374256 |
2006 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
rs1045642
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Similarly, the genotype distribution of 3435C>T and 2677G>T/A SNPs was not significantly different between Polish and Bosnian patients with CD (p > 0.05).
|
28759738 |
2017 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Two common single nucleotide polymorphisms (SNPs), C3435T and G2677T/A, thought to alter the function of the corresponding P-glycoprotein, have shown inconsistent associations with CD.
|
19107781 |
2009 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In this study, the G2677T/A polymorphism observed in the MDR1 gene was not found to be a risk factor for Crohn's disease or ulcerative colitis.
|
19115152 |
2008 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects.
|
17260353 |
2007 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
To investigate the contribution of multidrug resistance 1 (MDR1) gene pharmacogenetics (G2677T/A and C3435T) to the efficacy of azathioprine in inducing remission in patients with Crohn's disease (CD).
|
17262810 |
2007 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC).
|
16374256 |
2006 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
rs2032582
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with CD and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
|
27603561 |
2016 |
|
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The CC genotypes of rs1128503 and rs1045642 in MDR1 gene were more frequent in Crohn's disease (CD) patients who were GC-dependent than in those responsive to GC (odds ratio [OR] 6.583, 95% confidence interval [CI] 1.760-24.628, P = 0.019 and OR 3.873, 95% CI 1.578-9.506, P = 0.009, respectively).
|
25346426 |
2015 |
|
rs1128503
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Five SNPs, rs1128503 (P = 0.02), rs1202184 (P = 0.008), rs1202186 (P = 0.02), rs2091766 (P = 0.03), and rs2235046 (P = 0.03) were nominally associated with noninflammatory CD.
|
19107781 |
2009 |