|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
|
28249185 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
|
27073970 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two recent papers associated candidate genes with brooding rumination, a possible cognitive endophenotype for depression, in children ages 8-14 years.Stone et al. reported that BDNF val66met polymorphism predicted brooding in adolescence.Woody et al. reported that children carrying at least one copy of a CRHR1 TAT haplotype reported less brooding than their peers in the presence of maternal depression.
|
27073970 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, one specific set of genes, the brain derived neurotrophic factor (BDNF), specifically the Val66Met polymorphism, may play a crucial role in AD-related depression.
|
27335045 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of BDNF Val66MET Polymorphism With Parkinson's Disease and Depression and Anxiety Symptoms.
|
27852165 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
|
28249185 |
2017 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).
|
26681493 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
At 12 months, among those with depression, Met homozygotes (Val158Met) self-reported worse behavior than Val carriers (P = .015), and A2 homozygotes (Taq1a) self-reported worse behavior than A1 carriers (P = .028) in bivariable analysis.
|
27154305 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This exploratory study examined the association between exposure to stressful life events, polymorphisms (rs165774 and rs4680) in the catechol-O-methyltransferase (COMT) gene, and risk of depression in women.
|
27347613 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study.
|
26976307 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
|
26795846 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The influence of 5-HTTLPR and Val66Met polymorphisms on cortical thickness and volume in limbic and paralimbic regions in depression: a preliminary study.
|
26976307 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the BDNF val66met polymorphism and both depression status and treatment response were investigated using logistic regression models.
|
26795846 |
2016 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
|
26756166 |
2016 |
|
rs25531
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 5-HTTLPR polymorphism in the gene's promoter region has a short (S) and a long (L) allele, of which L contains a further SNP (rs25531), resulting in a triallelic polymorphism: La, Lg, and S. Both S and Lg result in increased serotonin signaling (to simplify, we refer to both alleles as 'S'), which in turn appears associated with depression vulnerability, specifically in individuals with stressful events.
|
26232751 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the effect of brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism on the severity of depressive and anxiety symptoms in never-smokers, former smokers, non-dependent, and nicotine-dependent smokers with a current diagnosis of depression and/or anxiety.
|
25618300 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met polymorphism and stressful life events in melancholic childhood-onset depression.
|
26462036 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the independent and interactive effects of BDNF methylation and val66met polymorphism on late-life depression.
|
25648279 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression.
|
25998702 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, the association between DED and Val66Met may vary by depression status.
|
26393465 |
2015 |