|
rs1333049
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Genotype CC of rs1333049 was significantly associated with both elevated CRP levels and decreased HDL concentrations after univariate (p = 0.028, p = 0.012) and multivariate analysis (p = 0.041, p = 0.023) stratified for age, gender, body mass index, smoking, diabetes, and severe periodontitis.
|
31770616 |
2020 |
|
rs1333049
|
|
|
0.740 |
GeneticVariation |
BEFREE |
For CHD patients, rs1333049 decreased the risk of diabetes under heterozygote (p = .014) and dominant (p = .024) models.
|
31496134 |
2019 |
|
rs1333049
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Genotyping of variant rs1333049 on chromosome 9p21.3 was performed in 2387 patients with and without diabetes who were undergoing coronary angiography to evaluate suspected or established CAD.
|
21362310 |
2011 |
|
rs1333049
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Significant associations were observed between 2 SNPs, rs1333049 on chromosome 9p21 and rs17465637 on chromosome 1q41, and MI, with odds ratios adjusted for age, sex, diabetes, hypertension and smoking habit of 1.47 (95% confidence interval (CI), 1.15-1.89; corrected p=0.006) and 1.45 (95%CI, 1.15-1.83; corrected p=0.006) for rs1333049 and rs17465637, respectively.
|
18654002 |
2008 |
|
rs2383207
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjustment of CAD risk factors such as smoking, family history of CAD and diabetes, the homozygous AA genotype for rs2383207 increased the CAD risk with an OR 3.69.
|
25333979 |
2015 |
|
rs2383207
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also replicated the associations for 9p21 (rs2383207, RR 1.13 per G allele, 95% CI 1.01-1.26, P = 0.036), as well as for male sex, systolic blood pressure, diabetes, cigarette smoking, low physical activity, coronary heart disease, and digoxin use (P<0.05).
|
22844511 |
2012 |
|
rs10757272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subjects with rs10757272 were found to have an increased odds ratio (OR) of having severe CAC in multivariate logistic regression analysis after adjusting for age, sex, hypertension, and diabetes (adjusted OR 3.24 and 95% CI 2.11-4.97).
|
30921371 |
2019 |
|
rs564398
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47).
|
29432124 |
2018 |
|
rs10757274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of diabetes was lower in patients carrying GG genotype for rs10757274, rs2383206 and rs10757278 (29.4%, 32.8%, 32.0%) compared to patients carrying AA or AG genotypes (49.1% and 39.2%, p = 0.01; 52.4% and 40.1%, p = 0.01; 47.8% and 37.9%, p = 0.04; respectively).
|
22856518 |
2012 |
|
rs2383206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the rs2383206 was still significantly associated with a 1.75-fold increased risk of overall mortality (p = 0.02) even after adjustment of a Cox multivariate model for age, previous myocardial infarction, diabetes, smoking and type of coronary anatomy.
|
22856518 |
2012 |
|
rs2811712
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs2222823 was significant (P= 0.035) in comparing S with H. In comparing S versus L, it is significant for the subgroups of patients without diabetes (P= 0.012) and drinking (P= 0.018). rs2811712 was significant in comparing S with L for the subgroups of patients with hyperlipidemia (P= 0.029) and drinking (P= 0.04).
|
22621687 |
2012 |
|
rs3217992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004).
|
20978019 |
2011 |
|
rs518394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the tagSNPs rs1360590, rs3217992, and rs518394, we could validate the associations with AgP before and after adjustment for the covariates smoking, gender and diabetes, with SNP rs3217992 being the most significant (OR 1.48, 95% CI 1.19 to 1.85; p=0.0004).
|
20978019 |
2011 |
|
rs7865618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, evidence was provided to suggest dual association of rs7865618 with MI and diabetes.
|
21511257 |
2011 |