|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Additionally, both omentin Val109Asp and FTO rs9939609 polymorphisms were significantly positively correlated to familial history of diabetes (P = 0.046 and P = 0.024, respectively).
|
31200723 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506).
|
28585683 |
2017 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
RESULTS Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P<0.05).
|
26873362 |
2016 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This was a cross-sectional study of 236 patients with type 2 diabetes (age 60.0 ± 10.3 years; diabetes duration 12.7 ± 8.2 years; 53.4% females) who were genotyped for FTO rs9939609.
|
23689376 |
2013 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene, especially the common rs9939609 (A/T) SNP, are associated with body mass index (BMI), diabetes, and metabolic syndrome (MetS).
|
21741858 |
2012 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238).
|
22466342 |
2012 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause.
|
21868005 |
2011 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up.
|
21179003 |
2011 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes.
|
21294771 |
2011 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)).
|
20057365 |
2010 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
For white participants, the FTO rs9939609 A allele was associated with an increased risk of diabetes (odds ratio (OR) = 1.19, p<0.001) and obesity (OR = 1.22, p<0.001) under an additive genetic model that was similar for all of the SNPs analyzed.
|
20502638 |
2010 |
|
rs8050136
|
|
|
0.030 |
GeneticVariation |
BEFREE |
RESULTS Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P<0.05).
|
26873362 |
2016 |
|
rs8050136
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The TCF7L2 rs7903146 and FTO rs8050136 polymorphisms, and particularly a weighted risk score of T2D risk alleles, predict diabetes after GDM.
|
22591707 |
2012 |
|
rs8050136
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)).
|
20057365 |
2010 |
|
rs1421085
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old.
|
28585683 |
2017 |
|
rs1421085
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In African-Americans, only the rs1421085 C allele was a determinant of obesity risk (OR = 1.17, p = 0.05), but was found to be protective against diabetes (OR = 0.79, p = 0.03).
|
20502638 |
2010 |
|
rs9926289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
rs9930506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No statistically significant difference was shown between the examined FTO polymorphism (rs9939609, rs1421085, and rs9930506) distribution between the subjects diagnosed with diabetes < 40 years , 40-60 years, and > 60 years old.
|
28585683 |
2017 |
|
rs7195539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The 4-locus interaction model, rs7195539-TG-HDL-family history of diabetes</span> had a cross-validation consistency of 8/10 (P<0.001).
|
26873362 |
2016 |
|
rs7204609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of C allele of the rs7204609 polymorphism (CT/CC genotypes, n = 35) were at increased risk for the presence of MetS (odds ratio [OR] = 4.56; 95% CI: 1.04 to 19.9), elevated waist circumference (OR = 8.66; 95% CI: 1.12 to 66.7), BMI: ≥ 30 kg/m(2) (OR = 3.71; 95% CI: 1.71 to 8.02), and microalbuminuria (OR = 2.30; 95% CI: 1.08 to 4.88), adjusted for gender and diabetes duration (P < .05 for all models).
|
21741858 |
2012 |