rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Gene-environment interaction analysis showed a significant interaction between rs13266634</span> in SLC30A8 gene and age on T2DM risk (P<0.0001).
|
24736664 |
2014 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634).
|
19033397 |
2009 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes.
|
27003436 |
2016 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D.
|
27310578 |
2016 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
When combined, each additional risk allele from CDKAL1-rs9465871, CDKN2A/B-rs10811661, IGF2BP2-rs4402960, and SLC30A8-rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)).
|
18633108 |
2008 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8.
|
18400535 |
2008 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations.
|
25875676 |
2015 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations.
|
26214053 |
2015 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
SLC30A8 (rs13266634) was the only type 2 diabetes variant associated with higher fasting glucose (0.033 mmol/l [0.01-0.06], P = 0.01).
|
19741166 |
2009 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We hypothesised that the correlation between autoantibody specificity for the ZnT8 Arg325Trp isoforms and the type 2 diabetes-associated rs13266634 may affect β-cell function at type 1 diabetes (T1D) onset.
|
20836749 |
2011 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D).
|
28965566 |
2017 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We observed an association between allele variants of SLC30A8 [rs13266634 (C/T)] and type 2-diabetes (P = 0.04).
|
25501231 |
2014 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion.
|
18162509 |
2008 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM.
|
27899481 |
2017 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Thus, we aimed to investigate the contribution of rs1111875 (HHEX), rs1800961 (HNF4α), rs5219 (KCNJ11), rs1801282 (PPARγ), rs10811661 (CDKN2A/2B), rs13266634 (SLC30A8), rs12779790 (CDC123/CAMK1D), rs7903146 (TCF7L2), rs9282541 (ABCA1) and rs13342692 (SLC16A11) polymorphisms in the genetic background of Maya population to associate their susceptibility to develop T2D.
|
25839936 |
2015 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
|
26832344 |
2016 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes.
|
30710592 |
2019 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The current study demonstrated a modest but significant effect of SLC30A8 (rs13266634) polymorphisms on T2D predisposition.
|
31823921 |
2019 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Our study suggested that the C allele of rs13266634 was associated with higher odds of T2D, and higher plasma zinc was associated with lower odds.
|
24306209 |
2014 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population.
|
28067832 |
2017 |
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |