|
rs770784511
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>SLC30A8</i> gene 807C/T polymorphism was significantly associated with an increased T2</span>DM risk in the Chinese population.
|
29875737 |
2018 |
|
rs7817754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one SNP (rs7817754) was significantly associated with incident T2D but a summary statistic based on all T2D-related traits identified 11 novel SNPs.
|
27896278 |
2016 |
|
rs16889462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with repaglinide therapeutic efficacy in Chinese T2DM patients.
|
20809084 |
2010 |
|
rs2466293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35.
|
21103332 |
2010 |
|
rs748727258
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs200185429
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D).
|
31676859 |
2019 |
|
rs200185429
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins.
|
24584071 |
2014 |
|
rs11558471
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We conclude that type 2 diabetes is associated with the AA genotype of rs11558471 in the human SLC30A8 gene.
|
22653633 |
2012 |
|
rs11558471
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
|
rs3802177
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied.
|
20550665 |
2010 |
|
rs3802177
|
|
|
0.820 |
GeneticVariation |
BEFREE |
A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1.
|
18477659 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes.
|
30710592 |
2019 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The current study demonstrated a modest but significant effect of SLC30A8 (rs13266634) polymorphisms on T2D predisposition.
|
31823921 |
2019 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A specific genetic variant, rs13266634 (c.973C>T; p.ARG325TRP) in zinc transporter SLC30A8/ZnT8, is associated with protection against Type-2 Diabetes, suggesting it may be actionable for predicting and preventing POHG.
|
31220282 |
2019 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044).
|
30142362 |
2018 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> The present meta-analysis demonstrated that <i>SLC30A8</i> rs13266634 was a potential risk factor for T2DM, and more studies should be performed to confirm the association between rs13266634 polymorphism and IGR.
|
30319545 |
2018 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The non-synonymous single nucleotide polymorphism (SNP) rs13266634 in human zinc transporter 8, ZnT8 (SLC30A8), leads to a R325 variant, which is associated with an increased risk of developing Type 2 Diabetes (T2D).
|
28965566 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
ZnT8 null mice have a mild phenotype with a slight decrease in glucose tolerance, whereas patients with the ZnT8 R325W polymorphism (rs13266634) have decreased proinsulin staining and susceptibility to T2DM.
|
27899481 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (<i>TCF7L2</i> rs7901695, <i>FTO</i> rs8050136, <i>HHEX</i> rs5015480, <i>SLC30A8</i> rs13266634 and <i>IGF2BP2</i> rs4402960) were observed in this study population.
|
28067832 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The solute carrier family 30 member 8 gene (<i>SLC30A8</i>) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in <i>SLC30A8</i> is associated with an increased risk of type 2 diabetes (T2D).
|
29093761 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W C-allele were more frequent in women with GDM compared to in controls (OR 1.47, 95 % CI 1.16-1.88, p = 0.0018) but not significantly increased in women with GDM and postpartum development of type 2 diabetes.
|
27003436 |
2016 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D.
|
27310578 |
2016 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
|
26832344 |
2016 |