|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our investigation confirmed the association between the KCNJ11 E23K variant and type </span>2 diabetes under a recessive model (KK vs EK+EE) in the Chinese Han population (odds ratio (OR)=1.25, 95% confidence interval (95% CI) 1.04-1.50, P=0.017).
|
19498446 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys).
|
15715885 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The polymorphism E23K on KCNJ11 that is associated with NIDDM was differentially distributed in the 2 cohorts.
|
17727257 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The current meta-analysis demonstrated that a modest but statistically significant effect of the 23K allele of rs5219 polymorphism in susceptibility to T2D.
|
24710510 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study replicated the association of rs5219 in KCNJ11 with type 2 diabetes in Chinese Han population in Beijing.
|
20079163 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic analysis revealed a novel variant (p.Pro190Leu) in HNF4A, which is located in the ligand binding domain of the transcription factor, and the p.Glu23Lys variant in KCNJ11, which is associated with type 2 diabetes.
|
26315042 |
2015 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The findings of the present study suggest that the KCNJ11 E23K variant is associated with a greater effect of sulphonylurea treatment in newly diagnosed Chinese patients with T2DM.
|
25115353 |
2014 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data indicate that HNF4A P2 promoter polymorphisms may interact with KCNJ11 E23K in predicting Type 2 diabetes in women.
|
17894829 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that the polymorphisms of the SUR1 gene predicted the conversion from impaired glucose tolerance to type 2 diabetes and that the effect of these polymorphisms on diabetes risk was additive with the E23K polymorphism of the Kir6.2 gene.
|
15579791 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population.
|
27253191 |
2017 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
|
22209866 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the present study, the association of the E23K polymorphism with type 2 diabetes was not significant (P = 0.26).
|
12540638 |
2003 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes.
|
20054294 |
2010 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs5219 (E23K) in KCNJ11 was associated with genetic susceptibility to type 2 diabetes (OR = 1.400 with 95% CI 1.117 1.755, P = 0.004 under an additive model, OR = 1.652 with 95% CI 1.086 2.513, P = 0.019 under a recessive model, and OR = 1.521 with 95% CI 1.089 2.123, P = 0.014 under a dominant model) after adjusting for sex and body mass index (BMI).
|
20079163 |
2009 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was a believable evidence to verify that rs5219 variation was associated with T2DM.
|
29685723 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, no significant association was observed between the KCNJ11 E23K gene polymorphism and T2D in the dominant genetic model (OR: 0.66, 95 % CI: 0.41-1.07, P = 0.09).The KCNJ11 E23K gene polymorphism is associated with T2D risk in the Chinese Han population.
|
23054005 |
2013 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program.
|
17259403 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association of KCNJ11 E23K and ABCC8 exon16-3T/C with the therapeutic effect of repaglinide in patients with type 2 diabetes.
|
18664331 |
2008 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
All the polymorphic loci in KCNJ11 are in strong linkage disequilibrium in the Korean population and act as one haplotype block. g.67G>A and g.1009A>G were associated with an increased risk of Type 2 diabetes [age, sex, and body mass index (BMI)-adjusted odds ratios (OR) = 1.376 (1.085-1.745), P = 0.008 and 1.411 (1.111-1.791), P = 0.005, respectively], as was one haplotype (A-T-A-C-G-C in the order of polymorphisms as shown above) containing g.67A and g.1009G [OR = 1.359 (1.080-1.709), P = 0.009].
|
17257281 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our results showed no evidence of a synergistic interaction between the KCNJ11 Glu(23)Lys and PPARG Pro(12)Ala polymorphisms, but indicated that they may act in an additive manner to increase the risk of type 2 diabetes.
|
15797964 |
2005 |