|
rs2285676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Triglycerides, DBP and KCNJ11 rs2285676 are predictors of the DPP-4 inhibitor treatment response in T2DM patients.
|
27249660 |
2016 |
|
rs5218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated whether the E23K (G→A, rs5219) or A190A (C→T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood pressure in the Chinese population.
|
25725792 |
2015 |
|
rs41282930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study of 400 T2D cases and controls of South Indian origin were performed to analyze the association of KCNJ11 polymorphisms (rs5219, rs5215, rs41282930, rs1800467) and copy number variations (CNV) on the risk of T2D.
|
25247988 |
2014 |
|
rs750778014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three novel KCNJ11 mutations, R27H, R192H and S116F117del, were identified in three families with early-onset type 2 diabetes mellitus.
|
24018988 |
2013 |
|
rs774714794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three novel KCNJ11 mutations, R27H, R192H and S116F117del, were identified in three families with early-onset type 2 diabetes mellitus.
|
24018988 |
2013 |
|
rs80356610
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C42R mutation in the Kir6.2 (KCNJ11) gene as a cause of transient neonatal diabetes, childhood diabetes, or later-onset, apparently type 2 diabetes mellitus.
|
15784703 |
2005 |
|
rs142577961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Common polymorphisms in these genes (ABCC8 exon 16-3t/c, exon 18 T/C, KCNJ11 E23K) have been variably associated with type 2 diabetes, but no large ( approximately 2,000 subjects) case-control studies have been performed.
|
12540637 |
2003 |
|
rs1800467
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among women with magnesium intake in the lowest 30% (AA: ≤0.164 g/d; HA: ≤0.185 g/d), 4 SNP signals were strengthened [rs11590362 in claudin 19 (CLDN19), rs823154 in SLC41A1, rs5929706 and rs5930817 in membra; HA: ≥0.313 g/d), rs6584273 in CNNM1 (OR: 0.71; FDR-adjusted P = 0.04) and rs1800467 in potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) (OR: 2.50; FDR-adjusted P = 0.01) were significantly associated with T2D risk.
|
25733456 |
2015 |
|
rs1800467
|
|
|
0.020 |
GeneticVariation |
BEFREE |
KCNJ11 rs5215, C-G-C-C haplotype and two loci analysis (rs5219 vs rs1800467) showed a significant association with T2D but CNV analysis did not show significant variation between T2D cases and control subjects.
|
25247988 |
2014 |
|
rs5210
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The <i>KCNJ11</i> SNP rs5210 was associated with T2DM, the <i>TCF7L2</i> SNP rs11196175 was associated with BMI and cholesterol and LDL levels, the <i>TCF7L2</i> SNP rs12255372 was associated with BMI and HDL, VLDL and triglyceride levels, and the <i>HNF4A</i> SNP rs1885088 was associated with LDL levels (P<0.05).
|
28352326 |
2017 |
|
rs5210
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evaluate the effect of these regions on genetic susceptibility for type 2 diabetes.
|
24065655 |
2013 |
|
rs5210
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The allelic and genotypic contrast demonstrated that the association between KCNJ11 and T2DM was significant for rs5210.
|
21573802 |
2012 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We found a lower risk of prediabetes and type 2 diabetes combined with coffee intake among individuals with the GT/TT of IGF2BP2 rs4402960, GG/GC of CDKAL1 rs7754840, or CC of KCNJ11 rs5215, which are known to be related to type 2 diabetes in East Asians.
|
25755232 |
2015 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
KCNJ11 rs5215, C-G-C-C haplotype and two loci analysis (rs5219 vs rs1800467) showed a significant association with T2D but CNV analysis did not show significant variation between T2D cases and control subjects.
|
25247988 |
2014 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We performed a comprehensive meta-analysis for KCNJ11 rs5219, rs5210, rs5215, and ABCC8 rs757110 to evaluate the effect of these regions on genetic susceptibility for type 2 diabetes.
|
24065655 |
2013 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
To examine the association of type 2 diabetes susceptibility loci and visceral fat accumulation, we genotyped 1279 Japanese subjects (556 men and 723 women), who underwent computed tomography for measurements of visceral fat area (VFA) and subcutaneous fat area (SFA) for the following single-nucleotide polymorphisms (SNPs): NOTCH2 rs10923931, THADA rs7578597, PPARG rs1801282, ADAMTS9 rs4607103, IGF2BP2 rs1470579, VEGFA rs9472138, JAZF1 rs864745, CDKN2A/CDKN2B rs564398 and rs10811661, HHEX rs1111875 and rs5015480, TCF7L2 rs7901695, KCNQ1 rs2237892, KCNJ11 rs5215 and rs5219, EXT2 rs1113132, rs11037909, and rs3740878, MTNR1B rs10830963, DCD rs1153188, TSPAN8/LGR5 rs7961581, and FTO rs8050136 and rs9939609.
|
22377712 |
2012 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11.
|
22569928 |
2012 |
|
rs5215
|
|
|
0.860 |
GeneticVariation |
BEFREE |
All the polymorphic loci in KCNJ11 are in strong linkage disequilibrium in the Korean population and act as one haplotype block. g.67G>A and g.1009A>G were associated with an increased risk of Type 2 diabetes [age, sex, and body mass index (BMI)-adjusted odds ratios (OR) = 1.376 (1.085-1.745), P = 0.008 and 1.411 (1.111-1.791), P = 0.005, respectively], as was one haplotype (A-T-A-C-G-C in the order of polymorphisms as shown above) containing g.67A and g.1009G [OR = 1.359 (1.080-1.709), P = 0.009].
|
17257281 |
2007 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Lys23Lys/CC combination was associated with a 2.65-fold increased likelihood of T2D (OR = 2.65, 95% CI 1.12-6.28), whereas the Glu23Lys/CT combination also increased such likelihood (OR = 3.88, 95% CI 1.27-11.91).
|
30467975 |
2019 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This study showed that rs5219 polymorphism of the KCNJ11 gene is an important risk factor for type 2 diabetes mellitus in a sample of the Syrian population.
|
31195986 |
2019 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was a believable evidence to verify that rs5219 variation was associated with T2DM.
|
29685723 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results suggest that E23K may have a greater effect on the development of T2D in female Chinese youth.
|
28449408 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Conclusion Both dominant and additive models in both KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genetic polymorphisms are significantly associated with type 2 diabetes.
|
29893194 |
2018 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs5219 at KCNJ11 (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population.
|
27253191 |
2017 |
|
rs5219
|
|
|
0.900 |
GeneticVariation |
BEFREE |
They also aid our understanding of how the Kir6.2-E23K variant predisposes to type 2 diabetes.
|
27118464 |
2016 |