Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE To explore the role of genetic variants of angiotensinogen (AGT M235T), angiotensin-converting enzyme (ACE I/D), and angiotensin type 1 receptor (AT1R A1166C) as predictors of diabetes risk and to examine their combined effects on type 2 diabetes mellitus (T2DM) patients. 20580725

2010

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE Gender-dependent effect of ACE I/D and AGT M235T polymorphisms on the progression of urinary albumin excretion in Taiwanese with type 2 diabetes. 18849600

2009

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE There were no differences in the frequencies of the AGT M235T and ACE I/D genotypes between Turkish patients with type 2 DM with and without nephropathy. 18413162

2008

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE ACE I/D polymorphism, but not AGT M235T polymorphism, may affect polyneuropathy development in type 2 diabetes without macroalbuminuria. 12449516

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese. 11776100

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them. 10352194

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.070 GeneticVariation BEFREE We studied the relationship of either an insertion-deletion polymorphism in the angiotensin-converting enzyme (ACE) gene and the M235T and T174M variant polymorphisms of the angiotensinogen (AGT) gene in non-insulin-dependent diabetes mellitus (NIDDM) patients and its relationship with cardiovascular complications. 9258285

1997

dbSNP: rs4343
rs4343
ACE
0.010 GeneticVariation BEFREE The ACE rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker potentially applicable for nutrigenetic dietary counseling. 28835639

2017

dbSNP: rs375442845
rs375442845
ACE
0.010 GeneticVariation BEFREE While Val762Ala polymorphism was associated with reduced susceptibility to DR, the Arg399Gln polymorphism contributed an elevated to risk for DR in South-Indian T2DM individuals. 24621175

2016

dbSNP: rs548450663
rs548450663
ACE
0.010 GeneticVariation BEFREE While Val762Ala polymorphism was associated with reduced susceptibility to DR, the Arg399Gln polymorphism contributed an elevated to risk for DR in South-Indian T2DM individuals. 24621175

2016

dbSNP: rs1330442011
rs1330442011
ACE
0.010 GeneticVariation BEFREE The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. 23468166

2014

dbSNP: rs775653132
rs775653132
ACE
0.010 GeneticVariation BEFREE The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. 23468166

2014

dbSNP: rs1205538057
rs1205538057
ACE
0.010 GeneticVariation BEFREE 1675G/A variant in the AT2R gene was found to be associated with CAD in female subjects with type 2 diabetes (p = 0.025). 22345093

2012

dbSNP: rs1241356540
rs1241356540
ACE
0.010 GeneticVariation BEFREE This study was designed to investigate whether V16A polymorphism of the manganese superoxide dismutase (Mn-SOD) gene is associated with the development of type 2 diabetes mellitus and with progression of diabetic retinopathy (DR) and diabetic macular edema (DME). 17142144

2006