|
rs3758391
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The polymorphisms rs3758391 and rs1800470 located in SIRT1 and TGF-β1 have been associated with type 2 diabetes in different populations but its functional effect is not clear.
|
31799723 |
2020 |
|
rs7896005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
|
rs3758391
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We failed to find any significant association between rs3758391 polymorphisms and T2DM, DF susceptibility.
|
29995800 |
2018 |
|
rs7896005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
|
30393491 |
2018 |
|
rs7896005
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two tag SNPs, rs10509291 and rs7896005, were nominally associated with type 2 diabetes (P=0.01, OR=1.25 95%CI 1.05-1.48, and P=0.02, OR=1.17 95%CI 1.02-1.34, respectively; additive P values adjusted for age, sex, birth year, and family membership), but not BMI (adjusted P values 0.52 and 0.45, respectively).
|
21871827 |
2011 |
|
rs3758391
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Nominally significant associations were also observed between T2D and the SIRT1 rs3758391 SNP and MS and the HHEX rs5015480 polymorphism.
|
20503258 |
2010 |
|
rs12778366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results were adjusted using logistic regression analysis.C allele of rs12778366 polymorphism was significantly correlated with reduced DF susceptibility which deriving from healthy controls (adjusted OR = 0.364, 95% CI = 0.158-0.835) so was patients with T2DM (P = .047, OR = 0.591, 95%CI = 0.349-0.998), but the results became nonsignificant adjusted by clinical features (adjusted OR = 0.654, 95% CI = 0.391-1.094).
|
29995800 |
2018 |
|
rs4746720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in <i>SIRT1</i> with rs4746720 CC+TT genotype increased the risk of T2DM, especially with the unhealthy eating habits.
|
30320001 |
2018 |
|
rs10823108
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, genetic variant rs10823108 in SIRT1 and variant rs17446614 in FoxO1 may contribute to the risk of DN in T2DM patients.
|
28860538 |
2017 |
|
rs1467568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles of these SNPs were associated with a lower prevalence of type 2 diabetes only in individuals who had been exposed to famine prenatally (odds ratio for rs7895833 0.50 [95% CI 0.24-1.03], P = 0.06; for rs1467568 0.48 [0.25-0.91], P = 0.02).
|
22228742 |
2012 |