|
rs1137100
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Interactions among moderate/severe periodontitis, rs1501299-GG, and rs1137100-GG were associated with an increased risk of T2DM.
|
31128439 |
2019 |
|
rs1137100
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present meta-analysis did not detect significant genetic associations between LEPR Q223R and K109R polymorphisms and T2D risk.
|
29293570 |
2018 |
|
rs1137101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present meta-analysis did not detect significant genetic associations between LEPR Q223R and K109R polymorphisms and T2D risk.
|
29293570 |
2018 |
|
rs1137101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs1137100
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP; 19G>A) gene and its receptor (LEPR; Q223R and K109R) are associated with birth weight and adult metabolic risk factors for type 2 diabetes in twins.
|
18490929 |
2008 |
|
rs1137101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we examined whether common single nucleotide polymorphisms (SNPs) in the leptin (LEP; 19G>A) gene and its receptor (LEPR; Q223R and K109R) are associated with birth weight and adult metabolic risk factors for type 2 diabetes in twins.
|
18490929 |
2008 |
|
rs1137100
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
rs1137101
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two polymorphisms (Lys109Arg, Gln223Arg) in the extracellular domain of the leptin receptor predicted the conversion to type 2 diabetes in high-risk individuals with IGT.
|
15997246 |
2005 |
|
rs1327118
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1327118 may be associated with SBP, DBP and HDL-C levels in women with T2DM, and rs3806318 may be associated with T2DM and SBP level in men with T2DM.
|
29301582 |
2018 |
|
rs3806318
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that rs1327118 may be associated with SBP, DBP and HDL-C levels in women with T2DM, and rs3806318 may be associated with T2DM and SBP level in men with T2DM.
|
29301582 |
2018 |
|
rs1045895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs1805092
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Particularly, gene polymorphisms in ADIPOQ (rs1501299 and rs17300539), LepR (rs1137101 and rs1045895), IRS2 (rs1805092), GRB14 (rs10195252 and rs3923113) and PPARG (rs1801282) have been associated with overweight and obesity in uncontrolled T2DM.
|
26999420 |
2016 |
|
rs13306519
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant interaction was observed between two SNPs rs13306519 in LEPR and rs266729 in ADIPOQ for T2DM (P_int = 0.012, OR_int = 2.67) and hypertension (P_int = 0.0041, OR_int = 2.23).
|
24414038 |
2014 |
|
rs1892534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms at the position rs10937273 in ADIPOQ and at the positions rs1892534 and rs2211651 in LEPR were statistically associated with early-onset T2DM (P=0.0246, 0.0014 and 0.0012, respectively).
|
21931325 |
2012 |
|
rs6700896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study was designed to assess the role of soluble leptin and LepRb in NAFLD and to investigate whether leptin receptor gene (LepR) single nucleotide polymorphism (SNP; ID rs6700896) influences NAFLD complicated with or without type 2 diabetes mellitus (T2DM).
|
22215535 |
2012 |
|
rs1805096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the relationship between human leptin receptor (LEPR) gene G3057A polymorphism and type 2 diabetes mellitus (T2DM) patients complicated with or without non-alcoholic fatty liver disease (NAFLD).
|
18713300 |
2009 |
|
rs1805094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Influence of Lys656Asn polymorphism of leptin receptor gene on insulin resistance in patients with diabetes mellitus type 2.
|
18632178 |
2008 |