|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overweight might modify the effects of rs660339 of UCP2 on T2DM.
|
29529994 |
2018 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we investigated whether UCP2 -866G/A, Ala55Val and Ins/Del polymorphisms were associated with DKD in patients with type 2 diabetes mellitus (T2DM), and whether they had an effect on UCP2 gene expression in human kidney tissue biopsies.
|
26218518 |
2015 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was significant difference in rs660339 between DM and controls (P = 0.0016; OR [95%CI] = 1.37 (1.14-1.65)).
|
25396419 |
2014 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Based on our case-control study and meta-analysis, we conclude that UCP2 Ala55Val and -866G/A polymorphisms are not significantly associated with type 2 diabetes risk in the Chinese population.
|
24065674 |
2013 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In our case-control study of people with European ancestry we were not able to demonstrate any association between the UCP polymorphisms and T2DM; however, our meta-analysis detected a significant association between the UCP2 Ala55Val and UCP3 -55C/T polymorphisms and increased susceptibility for T2DM in Asians.
|
23365654 |
2013 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Ala55Val and -55C/T polymorphisms at the UCP3-2 loci are associated with a significantly reduced risk of developing type 2 diabetes in Asian Indians.
|
21175267 |
2011 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, our results indicate that the UCP2 Ala55Val and UCP3 -55C/T polymorphisms may indeed be risk factors for susceptibility to type 2 diabetes in individuals of Asian descent, but not in individuals of European descent.
|
21751002 |
2011 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Ala55Val polymorphism of UCP2 was not associated with incident T2DM in the ARIC cohort.
|
18496642 |
2008 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the combination of the UCP2 55 Ala/Val heterozygote and the PPARgamma 161 C/C homozygote was associated with a reduced risk of Type 2 diabetes (odds ratio: 0.51, 95% CI: 0.34 to 0.77, p=0.0016).
|
14730379 |
2004 |
|
rs660339
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population.
|
9709950 |
1998 |
|
rs659366
|
|
|
0.020 |
GeneticVariation |
BEFREE |
All polymorphisms were in Hardy-Weinberg equilibrium, and the association by genotype with T2D-related traits displayed nominal significance for rs8192678 with glucose (<i>p</i> = 0.023) and triglycerides (<i>p</i> = 0.013); rs2010963 with diastolic blood pressure (DBP) (<i>p</i> = 0.012) and cholesterol (<i>p</i> = 0.013); rs7896005 with DBP (<i>p</i> = 0.012) and insulin (<i>p</i> = 0.011); and rs659366 with cholesterol (<i>p</i> = 0.034), glucose (<i>p</i> = 0.031) and triglycerides (<i>p</i> = 0.028); and the association of rs2010963 with HDL-C (<i>p</i> = 0.0007) was significant.
|
30393491 |
2018 |
|
rs659366
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, the UCP2 rs659366 polymorphism showed no significant difference between DM and control (P = 0.66; OR [95%CI] = 1.10 (0.91-1.32)).
|
25396419 |
2014 |
|
rs200027152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population.
|
9709950 |
1998 |