|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In this case-control study, the relationship of the -786T/C, the VNTR intron 4 a/b and the 894G/T (Glu298Asp) polymorphisms in the eNOS gene with the presence or severity of diabetic retinopathy was analyzed in 630 Caucasian-Brazilians with type 2 diabetes (434 with and 196 without diabetic retinopathy).
|
22017289 |
2012 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In both the cohorts, consistently lower prevalence and decreased risk of DR was observed in patients with ba, aa and ba + aa genotype of 27VNTR (a/b), C-a-G and C-a-T haplotype (allele of T-786C, 27VNTR a/b and G894T) carrying "C" allele of T-786C and "a" allele of 27VNTR (a/b).
|
23085930 |
2012 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, the G894T polymorphism does not appear to influence the development of DR.
|
22506535 |
2012 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Lower prevalence of mutant 4a (P = 0.011), and heterozygous 4b/4a (P = 0.042) were seen in the DR compared to the DWR groups; the allele and genotype distribution of the Glu298Asp and T-786C polymorphisms were comparable between DR and DWR groups.
|
17973941 |
2008 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We studied three eNOS genetic polymorphisms: a single nucleotide polymorphism in the promoter region (T(-786)C), in exon 7 (Glu298Asp), and a variable number of tandem repeats in intron 4 (b/a) in 103 healthy controls, and in 170 patients with T2DM (without DR, N=114; with DR, N=56).
|
16581274 |
2006 |
|
rs869109213
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Role of Genetic Variants (rs869109213 and rs2070744) Of the <i>eNOS</i> Gene and <i>Bgl</i>II in the α<sub>2</sub> Subunit of the α<sub>2</sub>β<sub>1</sub> Integrin Gene in Diabetic Retinopathy in a Tunisian Population.
|
31257963 |
2019 |
|
rs869109213
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found a significant association between the genotypes of NOS3 rs869109213 polymorphism and the risk of DR in the co-dominant model (4a4b genotype; 1.99-fold increased risk [1.09-3.65]; 95% confidence interval [CI]; p = 0.02), co-dominant model (4a4a genotype; 4.16-fold increased risk [1.03-16.74]; 95% CI; p = 0.04), and dominant model (4a4a and 4a4b genotypes; 2.22-fold increased risk [1.26-3.92]; 95% CI; p = 0.01) compared to the 4b4b genotype.
|
28817788 |
2018 |
|
rs2070744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Role of Genetic Variants (rs869109213 and rs2070744) Of the <i>eNOS</i> Gene and <i>Bgl</i>II in the α<sub>2</sub> Subunit of the α<sub>2</sub>β<sub>1</sub> Integrin Gene in Diabetic Retinopathy in a Tunisian Population.
|
31257963 |
2019 |
|
rs1549758
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings, supported by previous associations between eNOS4b/a polymorphism and DR, suggest that T-786C and C774T eNOS polymorphisms affect the onset pattern of severe DR.
|
15890549 |
2005 |