| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.030 | GeneticVariation | BEFREE | The results of our study demonstrated that the G allele of the Asp299Gly polymorphism of the TLR4 gene is associated with increased risk of cardiovascular disease and diabetic retinopathy in type 2 diabetes patients. | 27321310 | 2016 |
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|
0.030 | GeneticVariation | BEFREE | Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. | 21628510 | 2011 |
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|
0.030 | GeneticVariation | BEFREE | In conclusion, our results suggest an association between the Asp299Gly</span> polymorphism of the TLR4 gene and early onset of DR</span> in the DM2 patients. | 19135114 | 2009 |
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|
0.020 | GeneticVariation | BEFREE | This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population. | 25947554 | 2015 |
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|
0.020 | GeneticVariation | BEFREE | This study suggested that rs1927914 and rs1927911 were associated with type 2 diabetes mellitus and that rs1927914 was associated with susceptibility to DR in a Han Chinese population. | 25947554 | 2015 |
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|
0.020 | GeneticVariation | BEFREE | The present work was designed to investigate whether the TLR4 single nucleotide polymorphisms (SNPs) rs4986790, rs4986791, rs10759931, rs1927911, and rs1927914 are associated with DR in a north Indian population. | 24883015 | 2014 |
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|
0.020 | GeneticVariation | BEFREE | Results of the present case-control study that included 698 north Indian subjects suggested that TLR4 SNPs rs10759931 and rs1927914 modulate the risk of DR in T2DM cases. | 24883015 | 2014 |
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|
0.010 | GeneticVariation | BEFREE | Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. | 21628510 | 2011 |