rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the stratified analysis by ethnicity, the XRCC1 Arg399Gln</span> polymorphism had a higher risk of glioma development among Asians (for Gln vs Arg: OR = 1.34, 95 % CI 1.12-1.61; for GlnGln vs ArgArg: OR = 1.72, 95 % CI 1.18-2.51; for ArgGln vs ArgArg: OR = 1.31, 95 % CI 1.01-1.71; for GlnGln/ArgGln vs ArgArg: OR = 1.41, 95 % CI 1.10-1.80; for GlnGln vs ArgArg/ArgGln: OR = 1.48, 95 % CI 1.05-2.09)., but not among Caucasians.
|
23096083 |
2013 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study demonstrates that the rs25489 (Arg280His) and Arg399Gln</span> (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
|
25245010 |
2014 |
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population.
|
25375625 |
2014 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma.
|
26843108 |
2017 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there may be no association between the Arg280His polymorphism and glioma risk, whereas the Arg399Gln/Arg194Trp polymorphisms may contribute to genetic susceptibility to glioma in the Chinese population.
|
25375625 |
2014 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.
|
25245010 |
2014 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The rs25489 A/G genotype was also significantly associated with increased risk of glioma when compared with the A/A genotype (OR = 1.52; 95%CI = 1.03-2.35).
|
24634177 |
2014 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The rs2276466 G/G genotype was significantly associated with a moderate increased risk of glioma (OR=1.82, 95% CI=1.10-3.02) in a codominant model, and variation of rs25489 was associated with a 1.31- and 1.78-fold glioma risk in dominant and recessive models, respectively.
|
23911298 |
2013 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively.
|
23167420 |
2012 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln may be associated with the individual susceptibility to glioma.
|
24048757 |
2014 |
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma.
|
23712607 |
2013 |
rs1214285376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
rs148611340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.1779C>G, the genotype GG was statistically associated with the increased risk of glioma compared to wild genotype CC (OR = 1.80, 95% CI 1.17-2.78, P = 0.007).
|
23918303 |
2014 |
rs199613843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
rs2307191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
rs25490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.910A>G, the risk of glioma</span> for genotype GG was significantly higher than wild genotype AA (odds ratio (OR) = 1.98, 95% confidence interval (CI) 1.33-2.94, P = 0.001).
|
23918303 |
2014 |
rs72554204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.
|
24289608 |
2013 |