|
rs2230199
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In our series, the genotype GG of C3 rs2230199 was more significantly associated with the phenotype of large vascularized pigment epithelial detachment poorly responding to anti-vascular endothelial growth factor therapy than in global AMD series.
|
30681643 |
2020 |
|
rs2230199
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The associations of IL-8 rs4073 A→T, CFH rs1061170 T→C, ARMS2 rs10490924 G→T and C3 rs2230199 C→G SNPs with the presence of AMD and with the age of onset of exudative AMD were analysed.
|
26154559 |
2015 |
|
rs2230199
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In contrast, the C3 variants rs2230199 and rs1047286 were not associated with exudative AMD in the studied subjects.
|
19850835 |
2010 |
|
rs2230199
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
|
rs1047286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the C3 variants rs2230199 and rs1047286 were not associated with exudative AMD in the studied subjects.
|
19850835 |
2010 |
|
rs10411506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
|
rs163913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
|
rs2230205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |
|
rs2250656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of C3 IVS2 rs2250656 may be a significantly protective factor for neovascular AMD in the Chinese population.
|
19899988 |
2009 |
|
rs339392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033).
|
19899988 |
2009 |