|
rs11574129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant relationship was found in the HFMD cases of polymorphism rs11574129 (GA vs GG: odds ratio (OR) = 0.068, 95% confidence interval (CI) = 0.007-0.693, P = .023; GA + AA vs GG: OR = 0.322, 95%CI = 0.106-0.984, P = .047), and vitamin D levels in genotype AA were significantly higher than those in genotype GG (P < .05).
|
31587312 |
2020 |
|
rs908247294
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, genetic analyses showed all CA6 isolates belonged to lineage E2, and two amino acid changes of V174I and T283A in VP1 may be associated with the severity of HFMD.
|
31683008 |
2020 |
|
rs179019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele at the rs20541 locus of IL-13 gene and the A allele at the rs179019 locus of the TLR-7 gene were not risk factors for severe HFMD in either male or female patients.
|
30807256 |
2019 |
|
rs20541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele at the rs20541 locus of IL-13 gene and the A allele at the rs179019 locus of the TLR-7 gene were not risk factors for severe HFMD in either male or female patients.
|
30807256 |
2019 |
|
rs3853839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The allele C at TLR-7 rs3853839 locus is a risk factor for the severe HFMD caused by EV71 infection, which may be related to a reduction of the relative expression of TLR-7, IFN-α, and IL-6.
|
30807256 |
2019 |
|
rs9722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study demonstrated that the T allele at the rs9722 locus of the S100B gene was a significant risk factor for severe HFMD.
|
30807256 |
2019 |
|
rs3739674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity.
|
29235129 |
2018 |
|
rs5743305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity.
|
29235129 |
2018 |
|
rs9695310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity.
|
29235129 |
2018 |
|
rs1801253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the gene polymorphism of β1 adrenergic receptor G1165C have no significant correlation, not only with the susceptibility and severity of EV71 infection in hand, foot and mouth disease, but also with the levels of catecholamine.
|
28647185 |
2017 |
|
rs2843710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And rs2843710 allele G showed weaker transcriptional activity compared with allele C. Our study indicated that rs2843710</span> of IFNAR1 was associated with the susceptibility and severity of EV71 HFMD in Chinese Han populations, acting as a functional polymorphism by regulating ISGs expression, such as OAS1 and MX1.
|
26679744 |
2015 |
|
rs10774671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In short, the OAS1 rs10774671 SNP GG genotype contributed to CA16 susceptibility and was associated with the development of mild HFMD.
|
25059424 |
2014 |
|
rs41284767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single-nucleotide polymorphisms (SNP) [2'-5'-oligoadenylate synthetase1 (OAS1) rs10774671, selectin P ligand (SELPLG) rs2228315, scavenger receptor class B member 2 (SCARB2) rs41284767 and interleukin 28B (IL28B) rs12979860] were determined by Taqman assays in 333 HFMD samples and 163 control samples.
|
25059424 |
2014 |