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rs12979860
|
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|
0.100 |
GeneticVariation |
BEFREE |
In a recent genome-wide association study, a single nucleotide polymorphism (rs12979860) 3 kilobases upstream of the IL28B gene, which encodes the type III interferon IFN-3, was shown to associate strongly with more than a twofold difference in response to HCV drug treatment.
|
19759533 |
2009 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12979860 genotype is a significant independent predictor of response to PEG-IFN/RBV in patients with chronic HCV infection; tests for this genotype might be used to determine the best course of treatment for patients considering antiviral therapy.
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20176026 |
2010 |
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rs12979860
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|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.
|
20235331 |
2010 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs12979860 upstream of IL28B is associated with spontaneous clearance of HCV.
|
20637200 |
2010 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Independent predictors of SVR were HCV genotype 2-3 (odds ratio [OR], 13.98; 95% confidence interval [CI], 4.87-40.1; P < .001), rs12979860 CC (OR, 5.05; 95% CI, 2.04-12.5; P < .001), baseline plasma HCV RNA load of < or =600,000 IU/mL (OR, 1.99; 95% CI, 1.18- 3.34; P = .009), and female sex (OR, 4.28; 95% CI, 1.08-16.96; P = .039).
|
20804372 |
2010 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The final score included 4 variables: 2 host-related variables (IL28B SNP rs12979860 and liver stiffness) and 2 HCV-related variables (genotype and viral load).
|
20964522 |
2010 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further, we found significant differences in HCV RNA levels among individuals chronically infected with HCV genotype 1 for rs8103142 and rs12979860 (P ≤ 0.05).
|
21070502 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of the rs12979860 CC genotype is lower in HCV genotype 1 vs. genotype 2/3 patients.
|
21112657 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Common IL28B locus polymorphisms (SNPs rs8099917 and rs12979860) have been reported to affect peg-interferon plus ribavirin combination therapy (PEG-RBV) for hepatitis C virus (HCV) genotype 1b, but few reports have examined their effect on other two common genotypes, 2a and 2b.
|
21112660 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriers of the rs12979860 C allele associated with resolution of HCV infection exhibited increased IFN-lambda levels.
|
21145813 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (rs12979860 C/T) 3kb upstream of the interleukin 28B (IL-28B) gene was shown to be associated with hepatitis C clearance.
|
21146242 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Donor and recipient genotypes of IL28B rs12979860C>T single nucleotide polymorphism were determined in 91 patients with HCV liver graft reinfection, 47 of whom were treated with pegylated interferon-α (PEG-IFN-α) and ribavirin.
|
21147186 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with the donor genotype rs12979860 CC had higher peak ALT and HCV RNA serum concentrations than those with CT/TT (p=0.04 and 0.06, respectively).
|
21147186 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the association between IL28B single-nucleotide polymorphism rs12979860, hepatitis C virus (HCV) kinetic, and pegylated interferon alpha-2a pharmacodynamic parameters in HIV/HCV-coinfected patients from South America.
|
21157362 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the multivariate analyses for genotype 1 patients, the T allele of rs12979860 (T(rs12979860)) was an independent risk factor for a less pronounced first phase HCV RNA decline (log(10) 0.89IU/ml among T carriers vs. 2.06 among others, adjusted p < 0.001) and lower rapid (15% vs. 38%, adjusted p = 0.007) and sustained viral response rates (48% vs. 66%, adjusted p < 0.001).
|
21354446 |
2011 |
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rs12979860
|
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|
0.100 |
GeneticVariation |
BEFREE |
We found that the HCV genotype 1 responder genotypes at rs12979860 and rs8099917 did not associate with sustained virological response to PEG-IFN/ribavirin therapy.
|
21374656 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the AHC group, 31 (81.6%) rs12979860 CC carriers were infected with HCV genotype 1 or 4 vs. 32 (76.2%) among non-CC carriers (P=0.948).
|
21375685 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HIV/HCV-co-infected patients with the C allele (CC/CT) at rs12979860 show significantly higher plasma HCV-RNA load than TT carriers.
|
21378537 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed hepatovenous pressure gradient (HVPG), liver stiffness (transient elastography), and interleukin (IL)-28B polymorphisms (rs12979860) in 90 cirrhotic patients with HCV infection (82% genotype 1 or 4) before antiviral therapy with pegylated interferon and ribavirin.Efficacy and safety were evaluated.
|
21397726 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B SNP rs12979860 is a critical predictor for on-treatment and sustained virologic response in patients with hepatitis C virus genotype-1 infection.
|
21479134 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The widely accepted interleukin-28B (IL-28B) rs12979860 C/T polymorphism and the more recently proposed vitamin D serum concentration are two novel predictors of the response to antiviral treatment in chronic hepatitis C virus (HCV) infection.
|
21480318 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Real-time polymerase chain reaction assay based on high-resolution melting analysis for the determination of the rs12979860 polymorphism involved in hepatitis C treatment response.
|
21549150 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL28B rs12979860 CC genotype is associated with a higher prevalence of cirrhosis in HIV-HCV-coinfected patients than CT/TT genotypes, suggesting that IL28B CC carriers may experience a more rapid progression of HCV-related liver fibrosis, perhaps as result of increased liver inflammation.
|
21592993 |
2011 |
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rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Exposed, uninfected individuals had a significantly lower frequency of the protective genotype (rs12979860-CC) than anti-HCV-positive spontaneous resolvers (41.9% vs 69.7%, respectively; P=.0005; odds ratio [OR], 0.31; 95% confidence interval [CI]: 0.16-0.60) but a similar frequency to patients who were chronically infected (41.9% vs 43.6%, respectively; P=ns).
|
21600205 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients carrying CC(rs12979860) had higher baseline HCV RNA levels (P < .001) and did not, when treated for 12 weeks, achieve sustained virologic response more often than those carrying CT(rs1297986) or TT(rs1297986).
|
21606533 |
2011 |